Product image of Ibucalm (Ibuprofen) supplied by GNH India

Ibucalm

Active Ingredient:
Ibuprofen
Origin:
EU

Ibucalm (Ibuprofen)

Ibuprofen, the active ingredient in Ibucalm, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as a topical formulation for cutaneous, transdermal use. It relieves mild to moderate pain, reduces inflammation, and can be used for musculoskeletal discomfort in adults.

GNH India supplies Ibucalm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing consistent quality and regulatory compliance.

Manufacturer / TM Owner

Teva Pharma S.L.U.,

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Indications & Clinical Uses

Ibuprofen is an NSAID that reduces inflammation and pain through cyclooxygenase inhibition.

  • Mild to moderate pain: provides analgesic relief for headaches, dental pain, and minor injuries.
  • Inflammatory conditions: decreases swelling and discomfort in conditions such as tendonitis.
  • Musculoskeletal pain: alleviates aches associated with joints, muscles and back strain.
  • Fever: helps lower elevated body temperature in febrile states.

How It Works

  • Ibuprofen inhibits both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. Reduced prostaglandin synthesis diminishes peripheral sensitization of nociceptors, lowers inflammatory exudate formation, and resets the hypothalamic set‑point for temperature regulation, resulting in analgesic, anti‑inflammatory and antipyretic effects.

Side Effects

Common side effects are generally limited to the application site, while rare systemic reactions can be serious.

Common Side Effects

  • Skin irritation: redness, itching or mild burning at the site of application.
  • Local rash: transient erythema or maculopapular eruption.
  • Dryness: mild desquamation or peeling of the skin.
  • Pruritus: localized itching without swelling.

Serious or Rare Side Effects

  • Severe allergic reaction: anaphylaxis, angioedema, or bronchospasm.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Systemic toxicity: nausea, dizziness, or headache if absorbed in large amounts.
  • Gastrointestinal ulceration or bleeding (rare with topical use).

Precautions & Warnings

Before using Ibucalm, consider the following safety measures.

  • Skin integrity: avoid applying to broken, infected, or irritated skin.
  • Allergy: do not use if you have known hypersensitivity to ibuprofen or other NSAIDs.
  • Pregnancy: consult a healthcare professional; avoid use during the third trimester.
  • Concurrent NSAIDs: avoid using multiple NSAID products simultaneously to reduce additive toxicity.
  • Medical conditions: use cautiously in patients with cardiovascular disease, renal impairment, or asthma.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ibucalm may interact with other medicines; some combinations should be avoided while others require monitoring.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal and renal toxicity.
  • Lithium: ibuprofen can raise lithium serum concentrations.
  • Methotrexate: reduced clearance leading to potential toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible decline in renal function.
  • Diuretics: heightened risk of renal impairment.
  • Corticosteroids: increased chance of skin ulceration or systemic effects.

Frequently Asked Questions

Ibucalm is a topical ibuprofen product indicated for the relief of mild to moderate pain, reduction of localized inflammation, and management of musculoskeletal discomfort such as joint or muscle aches. It is applied to the skin over the affected area to provide targeted analgesic and anti‑inflammatory effects.

Ibuprofen, the active ingredient in Ibucalm, blocks the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for prostaglandin production. By lowering prostaglandin levels, the drug reduces the sensitisation of pain receptors, diminishes inflammatory swelling, and helps normalise body temperature when fever is present.

The specific dose and frequency of Ibucalm are determined by the prescribing healthcare professional based on the severity of symptoms, the size of the treatment area, and individual patient factors. Patients should follow the prescriber's instructions and the product label for proper application.

Ibucalm should be used with caution during pregnancy, especially in the third trimester, and only if the potential benefit outweighs the risk. Limited data are available for breastfeeding; therefore, a healthcare provider should be consulted before use to assess safety for both mother and infant.

To order Ibucalm, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Ibucalm contains ibuprofen, a well‑studied NSAID, and offers analgesic and anti‑inflammatory effects comparable to other topical NSAIDs such as diclofenac gel. Its transdermal delivery provides localized action with minimal systemic exposure, making it suitable for patients who prefer a non‑oral option while still achieving effective pain relief.

Ibucalm should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the container tightly closed when not in use and out of reach of children.

Ibucalm is applied topically to clean, dry skin over the painful or inflamed area. A thin layer is spread gently and rubbed in until absorbed. The exact amount and frequency depend on the prescriber's guidance, typically not exceeding the recommended number of applications per day.

Serious risks, though rare with topical use, include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, or toxic epidermal necrolysis. Systemic effects like gastrointestinal bleeding or renal impairment can occur if large amounts are absorbed, especially in patients with pre‑existing conditions.

Individuals with known hypersensitivity to ibuprofen, other NSAIDs, or any component of the formulation should avoid Ibucalm. It is also contraindicated in patients with active gastrointestinal ulcers, severe heart failure, or uncontrolled hypertension without medical advice.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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