Product image of Ibudol (Ibuprofen) supplied by GNH India

Ibudol

Active Ingredient:
Ibuprofen
Origin:
EU

Ibudol (Ibuprofen)

Ibuprofen, the active ingredient in Ibudol, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as a topical formulation for cutaneous use. It provides analgesic, anti‑inflammatory and antipyretic effects for mild to moderate pain and musculoskeletal inflammation.
GNH India supplies Ibudol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Kern Pharma, S.L.

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Indications & Clinical Uses

Ibudol, a topical NSAID, is employed to manage conditions involving pain and inflammation.

  • Mild to moderate pain: provides local analgesia without systemic exposure.
  • Musculoskeletal inflammation: reduces swelling and improves joint mobility.
  • Fever: offers modest antipyretic effect when applied to skin.
  • Post‑operative pain: alleviates discomfort at incision sites.
  • Dental pain: controls localized oral discomfort after procedures.

How It Works

  • Ibuprofen reversibly inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes in peripheral tissues, decreasing the synthesis of prostaglandins that mediate pain, inflammation and fever. By limiting prostaglandin production at the site of application, the topical formulation reduces local nociceptor sensitisation and inflammatory swelling.

Side Effects

Common Side Effects

  • Skin irritation: mild redness or warmth at the application site.
  • Itching: transient pruritus localized to the treated area.
  • Burning sensation: brief discomfort during or after application.
  • Dry skin: occasional flaking where the product is used.
  • Mild rash: non‑serious erythematous patches.

Serious or Rare Side Effects

  • Severe allergic reaction: anaphylaxis or angioedema requiring immediate medical attention.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: extensive skin detachment.
  • Severe skin ulceration: deep lesions beyond superficial irritation.
  • Systemic NSAID toxicity: renal impairment or gastrointestinal bleeding if absorbed in large amounts.
  • Cardiovascular events: rare thrombotic complications.

Precautions & Warnings

Before using Ibudol, consider the following precautions:

  • Renal function: assess kidney health, especially in patients with existing impairment.
  • Hypersensitivity: avoid if the patient has known allergy to ibuprofen or other NSAIDs.
  • Asthma: use with caution in individuals with aspirin‑exacerbated respiratory disease.
  • Concomitant NSAIDs: do not apply together with other topical or systemic NSAIDs to prevent additive toxicity.
  • Skin integrity: do not apply to broken, infected or severely damaged skin.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ibudol may interact with other medicines when absorbed systemically or when used concurrently with systemic agents.

Major Interactions (Avoid)

  • Oral anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Systemic NSAIDs: additive gastrointestinal and renal toxicity.
  • ACE inhibitors or ARBs: potential reduction in renal function.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance renal adverse effects.
  • Corticosteroids: increased risk of skin thinning and ulceration.

Frequently Asked Questions

Ibudol is a topical formulation of ibuprofen intended to relieve mild to moderate pain, reduce inflammation in musculoskeletal conditions, and provide modest antipyretic effect when applied to the skin. It is commonly used for joint aches, muscle soreness, and localized postoperative discomfort.

Ibuprofen in Ibudol works by reversibly inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes in peripheral tissues. This inhibition lowers prostaglandin production, which diminishes pain signalling, reduces inflammation, and helps lower fever at the site where the product is applied.

The appropriate amount of Ibudol to apply is determined by the prescribing healthcare professional based on the specific indication, patient age, and skin area involved. Patients should follow the prescriber’s instructions and the product label for the correct quantity and frequency of application.

The safety of topical ibuprofen during pregnancy or lactation has not been fully established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the use of Ibudol with their healthcare provider to weigh potential risks and benefits.

To request Ibudol, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and necessary import documentation.

Ibudol delivers ibuprofen directly to the skin, providing localized relief with lower systemic exposure compared with oral ibuprofen. This can reduce the risk of gastrointestinal and renal side effects, but the depth of analgesia may be limited to superficial tissues, whereas oral tablets affect the whole body.

Store Ibudol at room temperature, ideally below 25 °C. Keep the product in its original packaging, protect it from moisture, excessive heat and direct sunlight. Do not freeze the container, and ensure the cap is tightly closed to maintain product stability.

Ibudol is applied topically to clean, dry skin. The prescribed amount is spread thinly over the affected area and gently massaged until absorbed. Hands should be washed after application, and the product should not be covered with occlusive dressings unless directed by a healthcare professional.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome or toxic epidermal necrolysis, and systemic NSAID toxicity leading to renal impairment or gastrointestinal bleeding if significant absorption occurs. Patients should seek immediate medical attention if they notice widespread rash, blistering, or signs of an allergic reaction.

Ibudol should be avoided by individuals with known hypersensitivity to ibuprofen or any NSAID, those with active skin infections or open wounds at the intended site of application, and patients with a history of severe allergic skin reactions. Consultation with a healthcare professional is essential before use in these cases.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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