Product image of Ibufen (Ibuprofen) supplied by GNH India

Ibufen

Active Ingredient:
Ibuprofen
Origin:
EU

Ibufen (Ibuprofen)

Ibuprofen, the active ingredient in Ibufen, is a nonsteroidal anti-inflammatory drug presented as a rectal suppository for local administration. It is used to relieve mild to moderate pain, reduce fever, and treat inflammatory conditions such as musculoskeletal discomfort and dysmenorrhea.
GNH India supplies Ibufen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

  • Ibufen is an NSAID that acts on inflammatory pathways to alleviate several common conditions.
  • Mild to moderate pain: provides analgesia for headaches, toothaches, and musculoskeletal aches.
  • Fever: reduces elevated body temperature associated with infections or inflammatory states.
  • Inflammatory conditions: diminishes swelling and discomfort in musculoskeletal injuries.
  • Dysmenorrhea: eases menstrual cramps and associated pelvic pain.

How It Works

  • Ibuprofen reversibly inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels reduce inflammation, pain signaling, and fever generation at the site of tissue injury or infection.

Side Effects

Adverse reactions may occur with ibuprofen use and vary in frequency.

Common Side Effects

  • Gastrointestinal discomfort such as dyspepsia or heartburn.
  • Nausea or mild vomiting.
  • Headache.
  • Dizziness.
  • Mild skin rash or itching.
  • Elevated blood pressure in susceptible individuals.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Severe allergic reactions including anaphylaxis.
  • Hepatotoxicity or elevated liver enzymes.
  • Renal impairment or acute kidney injury.
  • Cardiovascular events such as myocardial infarction or stroke.
  • Blood dyscrasias like thrombocytopenia.

Precautions & Warnings

  • Before using Ibufen, consider the following safety measures.
  • Avoid in patients with known hypersensitivity to ibuprofen or other NSAIDs.
  • Use caution in individuals with a history of gastrointestinal ulcer or bleeding.
  • Monitor renal function in patients with existing kidney disease or dehydration.
  • Limit use in patients with uncontrolled hypertension or cardiovascular disease.
  • Do not combine with other NSAIDs or anticoagulants without medical advice.
  • Store at ambient temperature: keep in the original package, protect from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • High‑dose aspirin: heightened gastrointestinal toxicity.
  • Selective COX‑2 inhibitors: additive cardiovascular risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal perfusion.
  • Diuretics: potential for decreased renal function.
  • Lithium: ibuprofen can raise lithium serum levels.

Frequently Asked Questions

Ibufen is a rectal ibuprofen suppository indicated for relief of mild to moderate pain, reduction of fever, treatment of inflammatory conditions such as musculoskeletal discomfort, and alleviation of dysmenorrhea. It provides a local route of administration for patients who may have difficulty swallowing oral medications.

Ibuprofen, the active ingredient in Ibufen, blocks the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for prostaglandin synthesis. By lowering prostaglandin levels, it reduces inflammation, pain signaling, and fever responses at the site of tissue irritation.

The appropriate dose of Ibufen is determined by the prescribing healthcare professional based on the patient’s age, weight, and clinical condition. Patients should follow the prescriber’s instructions and not exceed the recommended amount.

The safety of ibuprofen suppositories during pregnancy has not been fully established, and it is generally advised to avoid use in the third trimester. Breastfeeding mothers should consult a healthcare provider, as ibuprofen can be excreted in breast milk.

To place an order, submit an enquiry on the Ibufen product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ibufen delivers ibuprofen via a rectal suppository, offering an alternative route for patients who cannot take oral tablets. Compared with oral ibuprofen, the suppository may provide faster onset in certain cases and bypasses the gastrointestinal tract, potentially reducing oral irritation but still sharing a similar safety profile.

Ibufen should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and extreme heat to maintain its stability and efficacy.

The suppository is inserted rectally, preferably after a bowel movement and before lying down. The patient should lie on their side with the upper leg drawn toward the abdomen, gently push the suppository in, and remain lying down for a few minutes to ensure proper absorption.

Serious risks include gastrointestinal ulceration or bleeding, severe allergic reactions such as anaphylaxis, renal impairment, and increased cardiovascular events like heart attack or stroke. Patients should seek immediate medical attention if they experience symptoms such as severe abdominal pain, vomiting blood, rash, swelling, or chest discomfort.

Ibufen should be avoided by individuals with known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal ulcers, severe renal or hepatic impairment, uncontrolled hypertension, or a history of cardiovascular disease without medical guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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