Product image of Ibuflam (Ibuprofen) supplied by GNH India

Ibuflam

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuflam (Ibuprofen)

Ibuprofen, the active ingredient in Ibuflam, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It is used to relieve pain, reduce fever, and lessen inflammation in adults and children when prescribed by a healthcare professional.

GNH India supplies Ibuflam as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for regulated markets. It offers comprehensive documentation and support for import compliance.

Manufacturer / TM Owner

Winthrop Arzneimittel Gmbh

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Indications & Clinical Uses

Ibuprofen is an NSAID that reduces pain, fever, and inflammation by inhibiting prostaglandin synthesis.

  • Pain: Provides relief from mild to moderate acute pain such as headache, dental pain, or musculoskeletal discomfort.
  • Fever: Lowers elevated body temperature associated with infections or inflammatory conditions.
  • Inflammation: Decreases swelling and stiffness in conditions like arthritis or soft‑tissue injuries.

How It Works

  • Ibuprofen exerts its effect by non‑selectively inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2. This inhibition blocks the conversion of arachidonic acid to prostaglandins, which are mediators of pain, fever, and inflammation. Reduced prostaglandin levels diminish the sensitization of nociceptors and the inflammatory response. By limiting prostaglandin production in peripheral tissues and the central nervous system, ibuprofen decreases vascular permeability, edema, and the activation of inflammatory cells.

Side Effects

Common and serious adverse reactions have been reported with ibuprofen use.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or mild abdominal pain.
  • Headache: transient headache occurring during therapy.
  • Dizziness: light‑headed sensation without loss of consciousness.
  • Rash: mild skin redness or itching.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding: severe stomach or intestinal lesions.
  • Renal impairment: reduced kidney function or acute kidney injury.
  • Cardiovascular events: increased risk of heart attack or stroke, especially with high‑dose or prolonged use.
  • Severe allergic reactions: anaphylaxis, angioedema, or bronchospasm.

Precautions & Warnings

When considering ibuprofen therapy, several safety measures should be observed.

  • Assess renal function: evaluate kidney health before initiating therapy in patients with pre‑existing renal disease.
  • Monitor gastrointestinal risk: use caution in individuals with a history of ulcers or bleeding.
  • Evaluate cardiovascular status: consider underlying heart disease or risk factors before long‑term use.
  • Review concomitant medications: avoid use with other NSAIDs, anticoagulants, or corticosteroids without medical guidance.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • High‑dose aspirin: enhanced gastrointestinal toxicity.
  • Selective COX‑2 inhibitors: additive renal and cardiovascular adverse effects.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function.
  • Diuretics: may potentiate renal impairment.
  • Lithium: ibuprofen can raise lithium serum levels.

Frequently Asked Questions

Ibuflam contains ibuprofen, an NSAID that is commonly prescribed to relieve mild to moderate pain, lower fever, and reduce inflammation associated with conditions such as headache, dental pain, musculoskeletal injuries, and arthritic disorders. It is used in both adult and pediatric patients when a healthcare professional determines it is appropriate.

Ibuprofen works by non‑selectively blocking the cyclooxygenase enzymes COX‑1 and COX‑2. This inhibition prevents the conversion of arachidonic acid into prostaglandins, which are key mediators of pain, fever, and inflammation. Lower prostaglandin levels result in decreased sensitisation of pain receptors and reduced inflammatory responses.

The appropriate dose of Ibuflam is determined by the prescribing clinician based on the patient’s age, weight, medical condition, and response to therapy. Dosage may vary from a single low dose for occasional pain to multiple doses per day for chronic conditions, and it should always follow the prescriber’s instructions.

Ibuprofen is generally avoided during the third trimester of pregnancy because it may affect fetal cardiovascular function. In earlier trimesters, use should only occur if clearly needed and prescribed by a qualified practitioner. Limited data exist for breastfeeding, and the drug may pass into milk; therefore, a healthcare professional should evaluate the risk‑benefit ratio.

To order Ibuflam, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details (including any cold‑chain requirements), and assists with import documentation.

Ibuflam (ibuprofen) shares the core NSAID properties of analgesia, antipyresis, and anti‑inflammation with agents such as naproxen and diclofenac. Compared with some NSAIDs, ibuprofen has a relatively short half‑life, which may allow flexible dosing but can require multiple daily administrations for sustained effect. Its safety profile is similar, though individual tolerability varies.

Ibuflam should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments. No special refrigeration is required for this oral formulation.

Ibuflam is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food may reduce gastrointestinal discomfort. The tablet (or other oral form) should be swallowed whole and not chewed or crushed unless specifically instructed by a healthcare professional.

Serious risks include gastrointestinal bleeding or ulceration, especially in patients with a history of ulcers or who use anticoagulants; renal impairment, which may manifest as reduced urine output or swelling; and cardiovascular events such as heart attack or stroke, particularly with high‑dose or prolonged therapy. Any signs of severe allergic reaction, such as swelling of the face or difficulty breathing, require immediate medical attention.

Ibuflam should be avoided by individuals with known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal bleeding or ulcer disease, patients with severe heart failure, uncontrolled hypertension, or significant renal impairment. It is also contraindicated in the third trimester of pregnancy and in patients taking certain anticoagulants or selective COX‑2 inhibitors without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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