Product image of Ibulysin (Ibuprofen) supplied by GNH India

Ibulysin

Active Ingredient:
Ibuprofen
Origin:
EU

Ibulysin (Ibuprofen)

Ibuprofen, the active ingredient in Ibulysin, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for systemic use. It is commonly employed to relieve mild to moderate pain, reduce fever, and manage inflammation associated with conditions such as arthritis. It is available across the European market and is recognized for its rapid onset of action and well‑established safety profile when used as directed.

GNH India supplies Ibulysin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality standards and regulatory requirements.

Manufacturer / TM Owner

Zentiva Pharma Gmbh

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Indications & Clinical Uses

Ibuprofen, an NSAID that reduces prostaglandin synthesis, is indicated for several common pain‑related and inflammatory conditions.

  • Mild to moderate pain: Provides analgesic relief for headaches, dental pain, musculoskeletal discomfort, and postoperative pain.
  • Fever: Lowers elevated body temperature associated with infections or inflammatory processes.
  • Inflammatory conditions: Decreases inflammation and improves mobility in arthritis and other musculoskeletal disorders.

How It Works

  • Ibuprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes peripheral sensitisation, lowers the hypothalamic set‑point for temperature, and curtails inflammatory mediators, resulting in analgesic, antipyretic, and anti‑inflammatory actions. By limiting prostaglandin E2 and other eicosanoids, ibuprofen also reduces vascular permeability and edema, contributing to its overall therapeutic profile.

Side Effects

Ibuprofen may cause a range of adverse reactions, varying from mild and transient to serious but uncommon.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
  • Headache or dizziness.
  • Rash or mild skin irritation.
  • Elevated blood pressure.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Severe allergic reactions: anaphylaxis or angioedema.
  • Renal impairment or acute kidney injury.
  • Cardiovascular events: myocardial infarction or stroke.

Precautions & Warnings

When using ibuprofen, several precautions should be observed to minimise risk and ensure safe therapy.

  • Assess renal function: avoid use in patients with severe renal impairment.
  • Monitor gastrointestinal risk: use lowest effective dose in those with ulcer history.
  • Evaluate cardiovascular status: caution in patients with heart disease or hypertension.
  • Review concomitant medications: avoid concurrent use with other NSAIDs or anticoagulants without supervision.
  • Pregnancy and lactation: consult healthcare professional before use during pregnancy or breastfeeding.
  • Store at ambient temperature: keep below 25°C in the original packaging, protected from moisture.

Avoid Interactions

Ibuprofen can interact with several medicines, altering efficacy or increasing toxicity.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • High‑dose aspirin: heightened gastrointestinal toxicity.
  • Selective COX‑2 inhibitors: additive renal and cardiovascular adverse effects.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce antihypertensive effect and impair renal function.
  • Diuretics: potential for reduced diuretic efficacy and renal compromise.
  • Lithium: ibuprofen may increase lithium serum levels.

Frequently Asked Questions

Ibulysin contains ibuprofen, an NSAID that is used to relieve mild to moderate pain, reduce fever, and treat inflammatory conditions such as arthritis. It is commonly prescribed for headaches, dental pain, musculoskeletal discomfort, and febrile illnesses.

Ibuprofen works by non‑selectively inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the synthesis of prostaglandins. Lower prostaglandin levels diminish pain signalling, lower the hypothalamic set‑point for temperature, and decrease inflammation and swelling.

The appropriate dose of Ibulysin is determined by the prescribing healthcare professional based on the individual’s condition, age, weight, and response to therapy. Patients should follow the prescriber’s instructions and not exceed the recommended amount.

Safety of ibuprofen during pregnancy or lactation depends on the trimester and clinical circumstances. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Ibulysin.

To order Ibulysin, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ibulysin (ibuprofen) belongs to the NSAID class and is comparable to agents such as naproxen or diclofenac. Compared with naproxen, ibuprofen generally has a shorter half‑life, which may require more frequent dosing but often results in a quicker onset of pain relief. All NSAIDs share similar gastrointestinal and cardiovascular risk profiles.

Ibulysin should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Ibulysin is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food or milk may reduce the likelihood of gastrointestinal discomfort.

Serious risks associated with ibuprofen include gastrointestinal ulceration or bleeding, severe allergic reactions such as anaphylaxis or angioedema, acute kidney injury, and cardiovascular events like myocardial infarction or stroke, especially with high‑dose or prolonged use.

Ibulysin should be avoided in individuals with known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal bleeding or ulcer disease, severe heart failure, or significant renal impairment. Patients on anticoagulant therapy should consult a physician before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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