Product image of Ibumetin (Ibuprofen) supplied by GNH India

Ibumetin

Active Ingredient:
Ibuprofen
Origin:
EU

Ibumetin (Ibuprofen)

Ibuprofen, the active ingredient in Ibumetin, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as an oral formulation for oral use. It treats mild to moderate pain, fever, and inflammatory conditions in adults and children as appropriate.

GNH India supplies Ibumetin as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orifarm Healthcare A/S

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Indications & Clinical Uses

Ibuprofen is an NSAID that reduces inflammation and pain through cyclooxygenase inhibition.

  • Mild to moderate pain: provides analgesic relief for headaches, dental pain, musculoskeletal discomfort, and postoperative pain.
  • Fever: lowers elevated body temperature associated with infections or inflammatory states.
  • Inflammatory conditions such as arthritis: decreases joint inflammation and improves mobility in osteoarthritis and rheumatoid arthritis.

How It Works

  • Ibuprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. Reduced prostaglandin synthesis diminishes inflammation, pain signaling, and fever generation at peripheral and central sites.

Side Effects

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
  • Headache: transient mild to moderate headache.
  • Dizziness: occasional light‑headedness.
  • Skin rash: mild erythematous eruptions.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Acute renal impairment, especially in volume‑depleted patients.
  • Severe allergic reactions, including anaphylaxis.
  • Hepatic injury presenting as elevated transaminases.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before initiating ibuprofen therapy, consider the following safety measures.

  • Assess renal function: avoid or adjust use in patients with significant kidney disease.
  • Monitor gastrointestinal risk: contraindicated in active peptic ulcer disease or recent GI bleeding.
  • Avoid concomitant anticoagulants: increased risk of serious bleeding.
  • Use the lowest effective dose for the shortest duration needed.
  • Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Concurrent use with anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Combination with other NSAIDs or aspirin: increased gastrointestinal toxicity.
  • Use with selective serotonin reuptake inhibitors (SSRIs): elevated risk of bleeding.

Moderate Interactions (Monitor Closely)

  • Co‑administration with ACE inhibitors or diuretics: may reduce renal function.
  • Concurrent lithium therapy: ibuprofen can raise lithium serum levels.
  • Use with methotrexate: potential increase in methotrexate toxicity.

Frequently Asked Questions

Ibumetin contains ibuprofen, an NSAID that is commonly used to relieve mild to moderate pain, reduce fever, and treat inflammatory conditions such as osteoarthritis and rheumatoid arthritis. It works by decreasing the production of prostaglandins, which are chemicals that promote inflammation, pain, and fever.

Ibuprofen works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes (COX‑1 and COX‑2). These enzymes are required for the conversion of arachidonic acid into prostaglandins, which mediate inflammation, pain, and fever. By reducing prostaglandin synthesis, ibuprofen alleviates these symptoms.

The appropriate dose of Ibumetin is determined by the prescribing healthcare professional based on the patient’s age, weight, medical condition, and response to therapy. Dosage recommendations are individualized and should follow the prescriber’s instructions and any applicable local regulations.

Ibuprofen is generally avoided during the third trimester of pregnancy because it may affect fetal cardiovascular function. Use during the first two trimesters should only occur if clearly needed and prescribed by a qualified clinician. Limited data are available for breastfeeding, and a prescriber should evaluate the risk‑benefit ratio before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Ibumetin. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details, and any necessary import documentation.

Ibumetin (ibuprofen) shares the core anti‑inflammatory and analgesic properties of other NSAIDs such as naproxen or diclofenac, but it has a relatively short half‑life, allowing flexible dosing. Its safety profile is comparable, though individual tolerance, gastrointestinal risk, and renal considerations may differ, making ibuprofen a common first‑line choice for many patients.

Ibumetin should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Ibumetin is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food or milk may reduce gastrointestinal discomfort. The exact administration schedule should follow the prescriber’s directions.

Serious risks include gastrointestinal bleeding or ulcer perforation, severe allergic reactions such as anaphylaxis, acute kidney injury, and rare but severe skin reactions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience symptoms such as vomiting blood, black stools, severe rash, or sudden swelling.

Ibumetin should be avoided in individuals with a known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal ulceration or bleeding, patients with severe renal or hepatic impairment, and in the third trimester of pregnancy. It should also be used with caution in patients taking anticoagulants, certain antihypertensives, or other NSAIDs.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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