Product image of Ibumetin (Ibuprofen) supplied by GNH India

Ibumetin

Active Ingredient:
Ibuprofen
Origin:
EU

Ibumetin (Ibuprofen)

Ibuprofen, the active ingredient in Ibumetin, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an oral tablet for oral administration. It provides analgesic, antipyretic and anti‑inflammatory effects, making it suitable for the relief of mild to moderate pain, reduction of fever, and management of inflammatory conditions in adults and, where approved, in pediatric patients.

GNH India supplies Ibumetin as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide and ensures reliable delivery across global markets.

Manufacturer / TM Owner

Orifarm Healthcare A/S

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Indications & Clinical Uses

Ibumetin (ibuprofen) is used to manage conditions involving pain, fever and inflammation.

  • Pain: Reduces mild to moderate acute pain such as headache, dental pain or musculoskeletal discomfort.
  • Fever: Lowers elevated body temperature associated with infections or inflammatory processes.
  • Inflammation: Decreases swelling and stiffness in conditions like osteoarthritis or rheumatoid arthritis.
  • Dysmenorrhea: Relieves menstrual cramps by reducing uterine prostaglandin production.

How It Works

  • Ibuprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which are key in the conversion of arachidonic acid to prostaglandins. By reducing prostaglandin synthesis, it diminishes peripheral sensitization of nociceptors, lowers the hypothalamic set‑point for temperature, and limits inflammatory exudate formation, resulting in analgesic, antipyretic and anti‑inflammatory actions.

Side Effects

Ibumetin may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness: transient sensation of light‑headedness.
  • Rash: mild skin erythema or itching.

Serious or Rare Side Effects

  • Gastrointestinal bleeding: ulceration or hemorrhage in the stomach or intestines.
  • Renal impairment: reduced kidney function or acute kidney injury.
  • Cardiovascular events: increased risk of heart attack or stroke, especially with high‑dose or prolonged use.
  • Severe allergic reactions: anaphylaxis, angioedema or bronchospasm.

Precautions & Warnings

Before using Ibumetin, consider the following precautions to minimise risk.

  • Assess renal function: avoid use in patients with severe kidney disease or dehydration.
  • Evaluate gastrointestinal risk: use cautiously in individuals with a history of ulcers or bleeding.
  • Monitor cardiovascular status: limit use in patients with established heart disease or high thrombotic risk.
  • Use during pregnancy: consult a healthcare professional, as safety data are limited.
  • Avoid in children under 12 months: ibuprofen is not recommended for infants unless specifically prescribed.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Avoid Interactions

Ibumetin can interact with several medicines; awareness of these interactions helps ensure safe therapy.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: heightened gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): elevated chance of bleeding.
  • Corticosteroids: synergistic risk of ulceration.
  • Lithium: ibuprofen may raise lithium serum levels.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in renal function.
  • Diuretics: may enhance nephrotoxic potential.
  • Methotrexate: reduced clearance leading to toxicity.
  • Antihypertensives: ibuprofen may blunt their effect.
  • Antidiabetic drugs: potential alteration of glucose control.

Frequently Asked Questions

Ibumetin contains ibuprofen, an NSAID that is commonly used to relieve mild to moderate pain, reduce fever, and lessen inflammation associated with conditions such as arthritis, dental pain, headache, and menstrual cramps. It is an over‑the‑counter option for short‑term symptom management when directed by a healthcare professional.

Ibuprofen works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for converting arachidonic acid into prostaglandins. By lowering prostaglandin levels, it reduces the sensitisation of pain receptors, lowers the hypothalamic set‑point for body temperature, and diminishes inflammatory swelling.

The appropriate dose of Ibumetin is determined by the prescribing clinician based on the patient’s age, weight, medical condition, and response to therapy. Dosage recommendations are provided in the product labeling, but the final regimen should always be set by a qualified healthcare professional.

Safety of ibuprofen in pregnancy and lactation is not fully established. It is generally avoided during the third trimester because of potential fetal cardiovascular effects, and caution is advised throughout pregnancy. Breastfeeding mothers should consult a healthcare provider, as ibuprofen does pass into breast milk in small amounts.

To order Ibumetin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ibumetin (ibuprofen) shares the core NSAID properties of analgesia, antipyresis and anti‑inflammation with agents such as naproxen and diclofenac. Compared with some NSAIDs, ibuprofen has a relatively short half‑life, which may allow flexible dosing but may also require more frequent administration for sustained effect.

Ibumetin should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture and direct sunlight, and keep them out of reach of children.

Ibumetin is taken orally, usually with a glass of water. It can be taken with or without food; however, taking it with food or milk may reduce the likelihood of gastrointestinal discomfort. Swallow tablets whole; do not crush or chew them.

Serious risks include gastrointestinal bleeding or ulceration, especially in patients with a history of ulcers or who use anticoagulants; renal impairment, particularly in dehydrated or elderly individuals; and increased cardiovascular events such as heart attack or stroke with high‑dose or prolonged use.

Ibumetin should be avoided by individuals with known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal bleeding, severe renal or hepatic impairment, and patients in the third trimester of pregnancy. It is also contraindicated in children younger than 12 months unless specifically prescribed.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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