Product image of Ibuprofen 1 A Pharma (Ibuprofen) supplied by GNH India

Ibuprofen 1 A Pharma

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen 1 A Pharma (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen 1 A Pharma, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as an oral tablet for oral use. It is indicated for relief of mild to moderate pain, reduction of fever, and management of inflammatory conditions such as arthritis.
GNH India supplies Ibuprofen 1 A Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

1 A Pharma Gmbh

1
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Indications & Clinical Uses

Ibuprofen acts on the cyclo‑oxygenase pathway to alleviate pain, fever and inflammation.

  • Mild to moderate pain: provides analgesia for headaches, dental pain, and musculoskeletal discomfort.
  • Fever: reduces elevated body temperature associated with infections or inflammatory states.
  • Osteoarthritis: helps control joint pain and stiffness in degenerative joint disease.
  • Rheumatoid arthritis: contributes to reduction of inflammatory joint pain and swelling.
  • Menstrual cramps: eases dysmenorrhea by decreasing uterine prostaglandin production.

How It Works

  • Ibuprofen non‑selectively inhibits cyclo‑oxygenase‑1 (COX‑1) and cyclo‑oxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels reduce peripheral sensitisation of nociceptors, lower the hypothalamic set‑point for temperature, and diminish inflammatory exudate formation, resulting in analgesic, antipyretic, and anti‑inflammatory effects.

Side Effects

Adverse reactions may occur with ibuprofen use.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash or mild pruritus.
  • Elevated blood pressure in susceptible individuals.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Renal impairment or acute kidney injury.
  • Hepatotoxicity with elevated liver enzymes.
  • Severe hypersensitivity reactions, including Stevens‑Johnson syndrome.
  • Cardiovascular events such as myocardial infarction or stroke, particularly with high‑dose or prolonged use.

Precautions & Warnings

When considering ibuprofen therapy, certain precautions are recommended.

  • Cardiovascular risk: assess history of heart disease before use.
  • Gastrointestinal risk: avoid in patients with active ulcers or severe gastritis.
  • Renal function: monitor kidney parameters in patients with chronic kidney disease.
  • Pregnancy and lactation: use only if clearly needed and after professional advice.
  • Concomitant medications: review for potential interactions, especially anticoagulants.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ibuprofen may interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • High‑dose aspirin: additive gastrointestinal toxicity.
  • Selective COX‑2 inhibitors: heightened cardiovascular risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function.
  • Diuretics: may enhance renal impairment.
  • Lithium: ibuprofen can raise serum lithium levels.
  • Methotrexate: reduced clearance leading to toxicity.

Frequently Asked Questions

Ibuprofen 1 A Pharma is used to relieve mild to moderate pain such as headaches, dental pain, and musculoskeletal aches; to lower fever associated with infections or inflammation; and to manage inflammatory conditions like osteoarthritis and rheumatoid arthritis by reducing prostaglandin‑mediated inflammation.

Ibuprofen works by non‑selectively blocking the cyclo‑oxygenase enzymes COX‑1 and COX‑2, which are responsible for converting arachidonic acid into prostaglandins. By lowering prostaglandin production, it diminishes pain signaling, reduces fever, and limits inflammatory swelling.

The appropriate dose of Ibuprofen 1 A Pharma is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and response to therapy. Patients should follow the prescriber’s instructions and not exceed the recommended amount.

Safety of ibuprofen during pregnancy or lactation depends on the trimester and individual risk factors. It is generally avoided in the third trimester and should only be used in pregnancy or while breastfeeding if the prescriber judges that the benefits outweigh potential risks.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ibuprofen shares a similar mechanism with other non‑selective NSAIDs such as naproxen and diclofenac, but it has a relatively shorter half‑life, which may require more frequent dosing. Its safety profile is comparable, though individual tolerance and specific risk factors (e.g., cardiovascular or gastrointestinal) guide the choice of agent.

Ibuprofen 1 A Pharma should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keeping the product in a dry, cool environment helps maintain its stability and potency.

The product is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food may reduce gastrointestinal discomfort. The exact administration schedule should follow the prescriber’s directions.

Serious risks include gastrointestinal bleeding or ulceration, renal impairment, hepatotoxicity, severe allergic reactions such as Stevens‑Johnson syndrome, and increased cardiovascular events like heart attack or stroke, particularly with high‑dose or prolonged therapy.

Individuals with a known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulcers, severe heart failure, uncontrolled hypertension, advanced renal or hepatic disease, and those in the third trimester of pregnancy should avoid using this medication unless specifically directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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