Product image of Nureflex Für Kinder (Ibuprofen) supplied by GNH India

Nureflex Für Kinder

Active Ingredient:
Ibuprofen
Origin:
EU

Nureflex Für Kinder (Ibuprofen)

Ibuprofen, the active ingredient in Nureflex Für Kinder, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as a suppository for rectal use. It provides analgesic, antipyretic and anti‑inflammatory effects for children experiencing pain, fever or mild inflammation.

GNH India supplies Nureflex Für Kinder as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company ensures quality compliance with EU standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Reckitt Benckiser Deutschland Gmbh

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Indications & Clinical Uses

Ibuprofen acts systemically to reduce inflammation and pain, making it useful for several pediatric conditions.

  • Pain: Provides rapid relief of mild to moderate pain such as headache, toothache or postoperative discomfort.
  • Fever: Lowers elevated body temperature in children with febrile illnesses.
  • Inflammation: Reduces swelling associated with minor musculoskeletal injuries or inflammatory conditions.

How It Works

  • Ibuprofen inhibits the cyclooxygenase enzymes COX‑1 and COX‑2, blocking the conversion of arachidonic acid to prostaglandins. This suppression of prostaglandin synthesis diminishes inflammation, reduces fever by acting on the hypothalamic thermoregulatory centre, and alleviates pain through decreased peripheral sensitisation.

Side Effects

Ibuprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Stomach discomfort: mild abdominal pain or dyspepsia.
  • Nausea: feeling of queasiness, sometimes with vomiting.
  • Diarrhea: loose stools.
  • Headache: mild to moderate headache.
  • Rash: mild skin irritation or erythema.

Serious or Rare Side Effects

  • Gastrointestinal bleeding: ulceration or bleeding in the stomach or intestines.
  • Allergic reactions: hives, swelling, or anaphylaxis.
  • Kidney impairment: reduced renal function or acute kidney injury.
  • Liver injury: elevated liver enzymes or hepatitis.
  • Blood disorders: thrombocytopenia or anemia.

Precautions & Warnings

When using ibuprofen suppositories in children, several precautions should be observed to ensure safety.

  • Age restriction: not for children under 3 months without medical advice.
  • Dosage accuracy: use only the prescribed amount based on weight.
  • Existing conditions: avoid in children with known peptic ulcer disease or severe kidney impairment.
  • Concomitant NSAIDs: do not combine with other NSAIDs or aspirin.
  • Allergies: discontinue if signs of hypersensitivity appear.
  • Store at room temperature: keep in original packaging, protect from moisture and heat.

Avoid Interactions

Ibuprofen can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or aspirin: heightened gastrointestinal toxicity.
  • Corticosteroids: elevated risk of ulceration and bleeding.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal function, especially in dehydrated patients.
  • Diuretics: potential for decreased kidney perfusion.
  • Lithium: ibuprofen can raise lithium serum levels.
  • Methotrexate: may increase methotrexate toxicity.

Frequently Asked Questions

Nureflex Für Kinder is a rectally administered ibuprofen suppository designed to relieve mild to moderate pain, reduce fever, and lessen inflammation in children. It is commonly used for conditions such as headache, toothache, postoperative discomfort, and febrile illnesses.

Ibuprofen blocks the cyclooxygenase (COX‑1 and COX‑2) enzymes, which are essential for producing prostaglandins. By lowering prostaglandin levels, it reduces inflammation, eases pain signals, and helps the hypothalamus reset body temperature, thereby lowering fever.

The appropriate dose is determined by a qualified prescriber based on the child’s age, weight, and clinical condition. Healthcare professionals calculate the exact amount of suppository to use, and patients should follow that specific recommendation without self‑adjusting the dose.

Safety data for ibuprofen in pregnancy and lactation are limited. It is generally advised to avoid use during the third trimester of pregnancy and to consult a physician before using it while breastfeeding. The prescriber will weigh potential benefits against possible risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and required import documentation.

The primary alternative for pediatric fever and pain is paracetamol (acetaminophen). Unlike paracetamol, ibuprofen also possesses anti‑inflammatory activity and can be more effective for swelling. However, ibuprofen carries a higher risk of gastrointestinal irritation and must be used with caution in children with certain medical conditions.

Store the suppositories at room temperature, preferably below 25 °C, in the original blister pack to protect them from moisture and heat. Keep them out of reach of children and avoid exposure to direct sunlight or excessive humidity.

The suppository is inserted rectally, usually after the child has emptied the bowels. The caregiver should wash hands, lubricate the tip if needed, and gently place the suppository into the rectum, ensuring it is positioned correctly for optimal absorption.

Serious adverse events include gastrointestinal bleeding or ulceration, severe allergic reactions such as anaphylaxis, and acute kidney injury, especially in dehydrated children or those with pre‑existing renal disease. Immediate medical attention is required if any of these symptoms appear.

Children with known hypersensitivity to ibuprofen or any NSAID, those with active peptic ulcer disease, severe kidney or liver impairment, or who are receiving anticoagulant therapy should avoid this product unless a physician explicitly advises otherwise.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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