Nurofen Med Jordbærsmak (Ibuprofen)

Ibuprofen is an NSAID that reduces pain, fever, and inflammation by acting on prostaglandin pathways.

• Pain: provides relief of mild to moderate pain such as headache, toothache, or musculoskeletal discomfort.
• Fever: lowers elevated body temperature associated with infections or inflammatory conditions.
• Inflammation: decreases swelling and discomfort in conditions like arthritis or minor injuries.

• Ibuprofen inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. By reducing prostaglandin synthesis, it diminishes the inflammatory response, lowers pain signaling, and helps regulate body temperature, resulting in analgesic, antipyretic, and anti‑inflammatory effects.

Common Side Effects

• Nausea: mild stomach upset or queasiness.
• Dyspepsia: indigestion or heartburn.
• Headache: transient head pain.
• Dizziness: feeling light‑headed or unsteady.
• Rash: mild skin irritation or redness.
• Diarrhea: loose stools.

Serious or Rare Side Effects

• Gastrointestinal bleeding: blood in stool or vomiting blood.
• Peptic ulceration: painful sores in the stomach or duodenum.
• Renal impairment: reduced kidney function or swelling.
• Severe allergic reactions: anaphylaxis, swelling of face or throat.
• Stevens‑Johnson syndrome: severe skin blistering.
• Hepatic injury: jaundice or abnormal liver enzymes.

Before using ibuprofen, consider the following precautions.

• Medical history: assess for ulcers, kidney disease, cardiovascular issues, asthma, or pregnancy.
• Hypersensitivity: avoid if known allergy to ibuprofen or other NSAIDs.
• Dose minimization: use the lowest effective dose for the shortest duration.
• Renal monitoring: check kidney function in patients with pre‑existing renal impairment or dehydration.
• Alcohol use: limit alcohol intake to reduce gastrointestinal risk.
• Store at ambient temperature: keep below 25°C, retain in original packaging, and protect from moisture.

Ibuprofen can interact with several medicines; monitoring is essential.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• Other NSAIDs or aspirin: heightened gastrointestinal toxicity.
• Corticosteroids: synergistic ulcer risk.
• Lithium: elevated lithium serum levels.
• Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in renal function.
• Diuretics: potential for decreased kidney perfusion.
• SSRIs: modest increase in bleeding tendency.
• Digoxin: may increase serum concentrations.
• Oral hypoglycemics: possible alteration of blood glucose control.