Nurofen Για Παιδιά (Φράουλα) (Ibuprofen)

Ibuprofen acts systemically to relieve inflammation‑related discomfort and fever in the pediatric population.

• Fever: lowers elevated body temperature associated with viral or bacterial infections.
• Mild to moderate pain: eases headache, toothache, sore throat, and ear pain.
• Minor musculoskeletal discomfort: reduces pain from sprains, strains, or mild joint inflammation.

• Ibuprofen inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain, and fever. By reducing prostaglandin levels at the site of injury and in the hypothalamic thermoregulatory center, it provides analgesic, antipyretic, and anti‑inflammatory effects without directly acting on the central nervous system.

Adverse reactions may occur with ibuprofen use in children.

Common Side Effects

• Stomach upset or abdominal pain
• Nausea or vomiting
• Diarrhea
• Headache
• Dizziness
• Mild rash

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration
• Severe allergic reactions (anaphylaxis, angioedema)
• Liver enzyme elevation or hepatitis
• Acute kidney injury
• Stevens‑Johnson syndrome or toxic epidermal necrolysis
• Blood dyscrasias such as neutropenia

When using ibuprofen in children, consider the following safety measures.

• Age restriction: not recommended for infants under 6 months without medical advice.
• Allergies: avoid if known hypersensitivity to ibuprofen or other NSAIDs.
• Medical conditions: use cautiously in asthma, renal impairment, hepatic disease, or cardiovascular disorders.
• Drug interactions: consult a healthcare professional before combining with anticoagulants, other NSAIDs, or certain antihypertensives.
• Store at ambient temperature: keep below 25°C, retain in original packaging, and protect from moisture.

Ibuprofen may interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin) – increased bleeding risk.
• Other NSAIDs or aspirin – additive gastrointestinal toxicity.
• ACE inhibitors or ARBs – may reduce renal function.
• Diuretics – potential for reduced kidney perfusion.
• Lithium – increased lithium levels.

Moderate Interactions (Monitor Closely)

• Antihypertensives – possible attenuation of blood‑pressure control.
• Methotrexate – reduced clearance leading to toxicity.
• SSRIs – heightened risk of bleeding.
• Corticosteroids – synergistic risk of ulceration.
• Cyclosporine – increased nephrotoxicity.