Product image of Ibuprofen Ab (Ibuprofen) supplied by GNH India

Ibuprofen Ab

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Ab (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Ab, is a non‑steroidal anti‑inflammatory drug presented as an oral dosage form for oral use. It is used to relieve mild to moderate pain, reduce fever, and lessen inflammation associated with conditions such as osteoarthritis and rheumatoid arthritis.

GNH India supplies Ibuprofen Ab as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides reliable sourcing for bulk and retail needs. All shipments are accompanied by full documentation and regulatory compliance certificates.

Manufacturer / TM Owner

Aurobindo N.V.

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Indications & Clinical Uses

Ibuprofen acts as a non‑selective cyclooxygenase inhibitor to manage pain, fever and inflammatory conditions.

  • Mild to moderate pain: provides analgesic relief for headaches, dental pain, musculoskeletal discomfort, and menstrual cramps.
  • Fever: reduces elevated body temperature associated with infections or inflammatory processes.
  • Inflammation: diminishes swelling and redness in acute injuries or chronic inflammatory diseases.
  • Osteoarthritis: improves joint function and reduces pain in degenerative joint disease.
  • Rheumatoid arthritis: helps control pain and inflammation in autoimmune joint inflammation.

How It Works

  • Ibuprofen inhibits both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins and thromboxanes. This reduction in prostaglandin synthesis lowers inflammation, pain signaling, and fever generation at peripheral and central sites, while also affecting platelet aggregation through reduced thromboxane A2 production.

Side Effects

Adverse reactions may range from mild, transient events to serious, potentially life‑threatening conditions.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
  • Headache or dizziness.
  • Skin rash or mild itching.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Acute renal impairment or worsening of chronic kidney disease.
  • Cardiovascular events such as myocardial infarction or stroke.
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome, toxic epidermal necrolysis).
  • Anaphylaxis or other severe hypersensitivity reactions.

Precautions & Warnings

Before using ibuprofen, consider the following safety measures.

  • Assess renal function: avoid use in severe renal impairment or dehydration.
  • Evaluate gastrointestinal risk: use with caution in patients with a history of ulcers or bleeding.
  • Review cardiovascular history: limit use in patients with established heart disease or high thrombotic risk.
  • Avoid in third‑trimester pregnancy: potential fetal harm.
  • Use the lowest effective dose for the shortest duration needed.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: heightened gastrointestinal toxicity.
  • Corticosteroids: additive ulcer risk.
  • Lithium: elevated lithium serum levels.
  • Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in renal function.
  • Diuretics: risk of nephrotoxicity.
  • SSRIs: modest increase in bleeding tendency.
  • Antihypertensives: potential attenuation of blood‑pressure‑lowering effect.
  • Oral hypoglycemics: may affect glucose control.

Frequently Asked Questions

Ibuprofen Ab is indicated for the relief of mild to moderate pain, reduction of fever, and control of inflammation. It is commonly used in conditions such as headache, dental pain, musculoskeletal aches, osteoarthritis, and rheumatoid arthritis, where prostaglandin‑mediated inflammation contributes to symptoms.

Ibuprofen works by non‑selectively inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2. This blocks the conversion of arachidonic acid to prostaglandins, which are mediators of pain, fever, and inflammation. Lower prostaglandin levels reduce the perception of pain, lower body temperature, and diminish swelling.

The specific dose of Ibuprofen Ab is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and response to therapy. The prescriber will select the appropriate strength, frequency, and duration in accordance with local guidelines and the product label.

Safety of ibuprofen during pregnancy and lactation depends on the trimester and individual risk factors. It is generally avoided in the third trimester because of potential fetal complications. Breastfeeding mothers should consult a healthcare provider, as small amounts can pass into milk. The prescriber will weigh benefits against risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifying trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Ibuprofen is a non‑selective NSAID with a relatively short half‑life, offering effective analgesic, antipyretic, and anti‑inflammatory actions. Compared with agents like naproxen, ibuprofen may require more frequent dosing but often has a lower risk of prolonged gastrointestinal exposure. Choice of NSAID depends on patient comorbidities, dosing convenience, and safety profile.

Ibuprofen Ab should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children. Do not store in damp areas such as bathrooms or near heat sources.

Ibuprofen Ab is intended for oral administration. The tablet or capsule should be swallowed whole with a full glass of water, preferably with food or milk to reduce gastrointestinal irritation. Do not crush, chew, or dissolve the dosage form unless specifically instructed by a healthcare professional.

Serious risks include gastrointestinal bleeding or ulcer perforation, acute renal failure, cardiovascular events such as heart attack or stroke, severe skin reactions (e.g., Stevens‑Johnson syndrome), and anaphylaxis. Patients with a history of ulcers, kidney disease, heart disease, or hypersensitivity should be monitored closely or avoid use.

Ibuprofen Ab should be avoided in individuals with known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulceration, severe renal or hepatic impairment, uncontrolled hypertension, and in the third trimester of pregnancy. Patients on anticoagulants, certain antihypertensives, or other NSAIDs should consult a clinician before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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