Product image of Ibuprofen Actavis (Ibuprofen) supplied by GNH India

Ibuprofen Actavis

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Actavis (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Actavis, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a tablet for oral use. It relieves mild to moderate pain, reduces fever, and decreases inflammation in adults and children as appropriate.

GNH India supplies Ibuprofen Actavis as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Actavis Group Ptc Ehf.

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Indications & Clinical Uses

Ibuprofen is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.

  • Mild to moderate pain: provides analgesic relief for headaches, dental pain, musculoskeletal discomfort.
  • Fever: lowers elevated body temperature.
  • Osteoarthritis: helps manage chronic joint pain and stiffness.
  • Rheumatoid arthritis: reduces inflammation and pain associated with the disease.

How It Works

  • Ibuprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which decreases the synthesis of prostaglandins involved in pain, fever, and inflammation pathways. This reduction in prostaglandin production leads to analgesic, antipyretic, and anti‑inflammatory outcomes.

Side Effects

Ibuprofen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness: transient sensation of light‑headedness.
  • Rash: mild skin irritation or itching.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding: potentially life‑threatening.
  • Severe hypersensitivity: anaphylaxis or angioedema.
  • Renal impairment: acute kidney injury, especially with dehydration.
  • Hepatotoxicity: elevated liver enzymes or jaundice.

Precautions & Warnings

Before using Ibuprofen Actavis, consider the following safety measures.

  • Assess renal function: avoid use in severe kidney disease without medical supervision.
  • Monitor cardiovascular risk: use cautiously in patients with hypertension or heart disease.
  • Avoid in active peptic ulcer: risk of bleeding may increase.
  • Limit alcohol consumption: may enhance gastrointestinal irritation.
  • Check for drug allergies: discontinue if signs of hypersensitivity appear.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.

Avoid Interactions

Ibuprofen can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • High‑dose aspirin: additive gastrointestinal toxicity.
  • Selective COX‑2 inhibitors: heightened cardiovascular risk.
  • ACE inhibitors or ARBs: may reduce renal protective effects.
  • Lithium: NSAIDs can raise lithium levels.

Moderate Interactions (Monitor Closely)

  • Diuretics: may diminish diuretic response.
  • Methotrexate: possible increased toxicity.
  • Corticosteroids: higher ulcer risk.
  • SSRIs or SNRIs: elevated bleeding potential.
  • Antihypertensives: may blunt blood pressure control.

Frequently Asked Questions

Ibuprofen Actavis is used to relieve mild to moderate pain, lower fever, and reduce inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, dental pain, and common aches. It belongs to the NSAID class and is appropriate for short‑term symptom management when prescribed by a healthcare professional.

Ibuprofen works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for producing prostaglandins. By lowering prostaglandin levels, it diminishes the signals that cause pain, fever, and inflammation, providing relief in affected tissues.

The appropriate dose of Ibuprofen Actavis is determined by the prescribing clinician based on the patient’s age, weight, condition being treated, and overall health status. Patients should follow the prescriber’s instructions and never exceed the recommended amount.

Safety of ibuprofen during pregnancy and lactation is limited. It is generally avoided in the third trimester because of potential fetal cardiovascular effects, and caution is advised throughout pregnancy. Breastfeeding mothers should consult their healthcare provider, as ibuprofen can pass into breast milk in small amounts.

To order Ibuprofen Actavis, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Ibuprofen shares the core mechanism of COX inhibition with other NSAIDs, offering a balance of analgesic, antipyretic, and anti‑inflammatory effects. Compared with aspirin, it has a lower risk of gastric irritation at standard doses, while drugs like naproxen may provide longer duration of action. Choice depends on individual patient factors and physician judgment.

Ibuprofen Actavis should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Ibuprofen Actavis is taken orally with a full glass of water. It may be taken with food or milk to lessen stomach discomfort, but it can also be taken on an empty stomach if tolerated. Swallow tablets whole; do not crush or chew unless instructed by a healthcare professional.

Serious risks include gastrointestinal bleeding or ulceration, severe allergic reactions such as anaphylaxis, kidney injury especially in dehydrated patients, and increased cardiovascular events like heart attack or stroke in high‑risk individuals. Any signs of severe abdominal pain, blood in stool, rash, swelling, or breathing difficulty require immediate medical attention.

Ibuprofen Actavis should be avoided in individuals with known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulcer or bleeding, severe heart failure, advanced renal impairment, and in the third trimester of pregnancy. Patients on anticoagulants, certain antihypertensives, or with uncontrolled hypertension should consult their physician before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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