Product image of Ibuprofen Activase Pharmaceuticals Limited (Ibuprofen Bp) supplied by GNH India

Ibuprofen Activase Pharmaceuticals Limited

Active Ingredient:
Ibuprofen Bp
Origin:
EU

Ibuprofen Activase Pharmaceuticals Limited (Ibuprofen Bp)

Ibuprofen, the active ingredient in Ibuprofen Activase Limited, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It is used to relieve pain, reduce fever, and lessen inflammation in adults and children when appropriate.

GNH India supplies Ibuprofen Activase Limited as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support global distribution. Our logistics network ensures timely delivery across multiple continents.

Manufacturer / TM Owner

Activase Pharmaceuticals Limited

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Indications & Clinical Uses

Ibuprofen is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.

  • Pain: Provides analgesic effect for mild to moderate pain.
  • Fever: Lowers elevated body temperature.
  • Inflammation: Decreases swelling associated with musculoskeletal conditions.

How It Works

  • Ibuprofen reversibly inhibits both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, leading to decreased conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes peripheral sensitization of nociceptors, lowers fever set‑points in the hypothalamus, and limits inflammatory exudate formation.

Side Effects

Ibuprofen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness: transient sensation of light‑headedness.
  • Rash: mild skin irritation or erythema.
  • Elevated liver enzymes: transient laboratory changes.
  • Mild renal impairment: increased serum creatinine in susceptible individuals.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration.
  • Severe renal dysfunction or acute kidney injury.
  • Cardiovascular events: myocardial infarction or stroke.
  • Anaphylaxis: life‑threatening allergic reaction.
  • Hepatotoxicity: significant liver injury.
  • Blood dyscrasias: thrombocytopenia or neutropenia.

Precautions & Warnings

When prescribing ibuprofen, consider the following precautions to minimize risk.

  • Assess gastrointestinal risk: evaluate history of ulcers or bleeding.
  • Evaluate renal function: monitor creatinine in patients with kidney disease.
  • Monitor cardiovascular status: use lowest effective dose in patients with heart disease.
  • Use lowest effective dose: limit duration to the shortest period needed.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Store at ambient temperature: keep in the original container, protect from moisture.

Avoid Interactions

Ibuprofen can interact with other medicines; notable interactions include.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Corticosteroids: heightened ulcer risk.
  • Lithium: elevated lithium serum levels.
  • Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in renal function.
  • Diuretics: potential for decreased renal perfusion.

Frequently Asked Questions

Ibuprofen Activase Limited contains ibuprofen, an NSAID that is commonly used to relieve mild to moderate pain, reduce fever, and decrease inflammation associated with conditions such as musculoskeletal injuries, dental pain, and arthritic disorders.

Ibuprofen works by reversibly inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the synthesis of prostaglandins. Lower prostaglandin levels diminish pain signaling, lower fever, and limit the inflammatory response.

The appropriate dose of ibuprofen is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and response to therapy. Dosage instructions should always follow the prescriber’s recommendation and the product label.

Safety of ibuprofen in pregnancy and lactation depends on the trimester and individual risk factors. It is generally avoided in the third trimester and used with caution earlier in pregnancy. Breastfeeding mothers should consult their physician, as ibuprofen does cross into breast milk in small amounts.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with acetaminophen, ibuprofen provides both analgesic and anti‑inflammatory effects, making it useful for conditions where inflammation contributes to pain. Unlike opioids, ibuprofen has no risk of dependence, but it carries gastrointestinal, renal, and cardiovascular considerations that must be managed.

Ibuprofen tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original packaging, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Ibuprofen is administered orally, typically as a tablet, capsule, or liquid suspension. It should be taken with a full glass of water, and may be taken with food or milk to reduce potential gastrointestinal irritation.

Serious risks include gastrointestinal bleeding or ulceration, severe renal impairment, cardiovascular events such as heart attack or stroke, and rare but life‑threatening allergic reactions like anaphylaxis. Patients should seek immediate medical attention if they experience signs of these conditions.

Ibuprofen should be avoided in individuals with known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulcer disease, severe heart failure, uncontrolled hypertension, or those taking anticoagulants without medical supervision. Pregnant women in the third trimester should also refrain from using ibuprofen.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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