Product image of Ibuprofen Afl (Ibuprofen) supplied by GNH India

Ibuprofen Afl

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Afl (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Afl, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for systemic use. It is used to relieve pain, reduce fever, and diminish inflammation in adults and children when appropriate.

GNH India supplies Ibuprofen Afl as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for bulk and smaller scale orders across multiple regions. Customers benefit from comprehensive regulatory support and timely delivery.

Manufacturer / TM Owner

Aflofarm Farmacja Polska Sp. Z O.O.

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Indications & Clinical Uses

Ibuprofen acts on inflammatory pathways to provide relief in several common conditions.

  • Pain: Reduces mild to moderate pain such as headaches, dental pain, and musculoskeletal discomfort.
  • Fever: Lowers elevated body temperature associated with infections or inflammatory states.
  • Inflammation: Decreases swelling and stiffness in conditions like arthritis or soft‑tissue injuries.

How It Works

  • Ibuprofen inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. By reducing prostaglandin synthesis, it diminishes the inflammatory response, lowers pain‑signal sensitization, and decreases the hypothalamic set‑point for temperature regulation, resulting in analgesic, antipyretic, and anti‑inflammatory effects. The reversible binding to COX enzymes is dose‑dependent and provides systemic distribution after oral absorption, allowing therapeutic concentrations in peripheral tissues and the central nervous system.

Side Effects

Ibuprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or mild abdominal pain.
  • Headache: transient headache episodes.
  • Dizziness: light‑headedness or vertigo.
  • Skin reactions: mild rash or itching.

Serious or Rare Side Effects

  • Gastrointestinal bleeding: ulceration or hemorrhage in the stomach or intestines.
  • Renal impairment: reduced kidney function or acute kidney injury.
  • Cardiovascular events: increased risk of heart attack or stroke, especially with high‑dose or prolonged use.

Precautions & Warnings

When using ibuprofen, consider the following precautions to minimize risks.

  • Assess renal function: avoid use in patients with severe kidney disease or dehydration.
  • Monitor cardiovascular risk: use cautiously in individuals with hypertension, heart disease, or stroke history.
  • Evaluate gastrointestinal history: avoid in patients with active ulcers or a history of serious GI bleeding.
  • Review concomitant medications: be cautious with other NSAIDs, anticoagulants, or corticosteroids.
  • Store at ambient temperature: keep below 25°C in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can interact with several medicines; some require avoidance while others need close monitoring.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding potential.
  • ACE inhibitors or ARBs: may reduce antihypertensive effect and impair kidney function.

Moderate Interactions (Monitor Closely)

  • Diuretics: possible reduction in diuretic efficacy and renal perfusion.
  • Lithium: ibuprofen may raise lithium serum levels.
  • Methotrexate: decreased clearance leading to toxicity.

Frequently Asked Questions

Ibuprofen Afl contains ibuprofen, an NSAID that is commonly used to relieve mild to moderate pain, reduce fever, and lessen inflammation associated with conditions such as headaches, dental pain, musculoskeletal aches, and arthritis. It provides symptomatic relief in both adult and pediatric populations when prescribed by a healthcare professional.

Ibuprofen works by inhibiting the cyclooxygenase (COX‑1 and COX‑2) enzymes that convert arachidonic acid into prostaglandins. Prostaglandins are mediators of pain, fever, and inflammation; reducing their synthesis lowers the body’s inflammatory response, diminishes pain‑signal transmission, and resets the hypothalamic temperature set‑point.

The appropriate dose of Ibuprofen Afl is determined by the prescribing clinician based on the patient’s age, weight, severity of symptoms, and any underlying medical conditions. Dosage recommendations may differ for short‑term pain relief versus chronic inflammatory conditions, and the prescriber will adjust the regimen accordingly.

Ibuprofen is generally avoided during the third trimester of pregnancy because it may affect fetal cardiovascular function. Use in earlier trimesters should only occur if the potential benefit outweighs the risk and under medical supervision. Limited data suggest short‑term use is compatible with breastfeeding, but a healthcare provider should be consulted.

To place an order, submit an enquiry on the Ibuprofen Afl product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

The primary alternative to ibuprofen is acetaminophen (paracetamol), which provides analgesic and antipyretic effects but lacks significant anti‑inflammatory activity. Ibuprofen’s NSAID class offers stronger inflammation control but carries higher gastrointestinal and cardiovascular risk, whereas acetaminophen is gentler on the stomach but can affect liver function at high doses.

Ibuprofen Afl should be stored at ambient temperature, preferably below 25 °C, in its original container to protect it from moisture and direct sunlight. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments to maintain stability and potency.

Ibuprofen Afl is administered orally, typically as a tablet that is swallowed whole with a full glass of water. It may be taken with or without food; taking it with food can help reduce mild gastrointestinal discomfort. The exact administration schedule is set by the prescribing clinician.

Serious risks include gastrointestinal bleeding or ulceration, especially in patients with a history of ulcers or who use anticoagulants; renal impairment, which can manifest as reduced urine output or elevated creatinine; and cardiovascular events such as heart attack or stroke, particularly with high‑dose or long‑term therapy.

Individuals with known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal bleeding or severe ulcer disease, patients with advanced kidney failure, and persons who have had a recent coronary artery bypass graft surgery should avoid ibuprofen. Consultation with a healthcare professional is essential before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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