Ibuprofen Alkaloid-Int (Ibuprofen)

Ibuprofen Alkaloid-Int is an NSAID that acts on inflammatory pathways to relieve various types of pain.

• Pain relief: alleviates mild to moderate acute pain.
• Inflammation reduction: decreases swelling and redness in localized inflammatory conditions.
• Musculoskeletal pain: eases discomfort associated with muscles, joints and soft‑tissue injuries.

• Ibuprofen Alkaloid-Int inhibits cyclo‑oxygenase enzymes COX‑1 and COX‑2, which blocks the conversion of arachidonic acid to prostaglandins. By lowering prostaglandin synthesis, it reduces peripheral sensitisation, inflammation, pain signalling and fever generation at the site of application.

Adverse reactions may occur with topical ibuprofen use.

Common Side Effects

• Gastro‑intestinal upset: nausea or dyspepsia.
• Headache: mild to moderate intensity.
• Dizziness or light‑headedness.
• Skin irritation: redness, itching or burning at the application site.
• Rash or mild dermatitis.

Serious or Rare Side Effects

• Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Severe gastrointestinal bleeding or ulceration.
• Acute renal impairment or failure.
• Hepatic dysfunction or elevated liver enzymes.
• Anaphylactic reaction or severe hypersensitivity.
• Blood dyscrasias such as agranulocytosis or thrombocytopenia.

Before using Ibuprofen Alkaloid-Int, consider the following safety measures.

• Renal function assessment: avoid in severe renal impairment.
• Gastro‑intestinal risk evaluation: use cautiously in patients with a history of ulcers or bleeding.
• Cardiovascular review: monitor patients with hypertension or heart disease.
• Pregnancy caution: avoid in the third trimester; category B in earlier trimesters.
• Asthma consideration: use with caution in patients with aspirin‑sensitive asthma.
• Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Ibuprofen Alkaloid-Int can affect or be affected by other medicines.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• Other NSAIDs or aspirin: additive gastrointestinal toxicity.
• ACE inhibitors (e.g., enalapril): may reduce renal perfusion.

Moderate Interactions (Monitor Closely)

• Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding potential.
• Systemic corticosteroids: increased ulcer risk.
• Methotrexate: reduced clearance leading to toxicity.