Product image of Ibuprofen Alkem (Ibuprofen) supplied by GNH India

Ibuprofen Alkem

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Alkem (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Alkem, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an oral dosage form for systemic use. It is used to relieve mild to moderate pain, reduce fever, and manage inflammation in conditions such as arthritis.

GNH India supplies Ibuprofen Alkem as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for global healthcare providers. Our distribution network ensures timely delivery and regulatory compliance across multiple regions.

Manufacturer / TM Owner

Ascend Gmbh

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Indications & Clinical Uses

Ibuprofen acts on inflammatory pathways to provide analgesic, antipyretic and anti‑inflammatory effects.

  • Mild to moderate pain: reduces pain intensity and improves functional ability.
  • Fever: lowers elevated body temperature.
  • Osteoarthritis: alleviates joint pain and improves mobility.
  • Rheumatoid arthritis: decreases inflammation and pain in affected joints.
  • Inflammatory conditions: reduces swelling and discomfort.

How It Works

  • Ibuprofen reversibly inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins and thromboxanes. This reduction in prostaglandin synthesis diminishes peripheral sensitization of nociceptors, lowers the hypothalamic fever set‑point, and curtails inflammatory mediators, resulting in analgesic, antipyretic and anti‑inflammatory actions.

Side Effects

Ibuprofen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness: transient light‑headedness.
  • Rash: mild skin irritation or erythema.
  • Diarrhea: loose stools without blood.
  • Elevated liver enzymes: mild, transient changes.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Renal impairment or acute kidney injury.
  • Hepatotoxicity with marked liver enzyme elevation.
  • Severe allergic reactions such as anaphylaxis.
  • Cardiovascular events including myocardial infarction or stroke.
  • Blood dyscrasias such as thrombocytopenia.

Precautions & Warnings

When using Ibuprofen, consider the following safety measures.

  • Assess renal function: monitor kidney parameters in patients with pre‑existing renal disease.
  • Evaluate gastrointestinal risk: use the lowest effective dose and consider gastro‑protective agents in high‑risk individuals.
  • Avoid in patients with known hypersensitivity to ibuprofen or other NSAIDs.
  • Use caution in cardiovascular disease: NSAIDs may increase risk of thrombotic events.
  • Limit use during the third trimester of pregnancy: may affect fetal cardiovascular function.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and heat.

Avoid Interactions

Ibuprofen can interact with several medicines; awareness of major and moderate interactions helps minimize risk.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • High‑dose aspirin: enhanced renal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding risk.
  • Lithium: ibuprofen may increase lithium serum levels.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal function.
  • Diuretics: potential for reduced efficacy and renal impairment.
  • Methotrexate: decreased clearance leading to toxicity.
  • Corticosteroids: increased risk of gastrointestinal ulceration.

Frequently Asked Questions

Ibuprofen Alkem is an oral NSAID indicated for the relief of mild to moderate pain, reduction of fever, and management of inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis and other inflammatory disorders.

Ibuprofen works by reversibly inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the synthesis of prostaglandins. Lower prostaglandin levels diminish pain signalling, lower fever, and decrease inflammation at the site of injury or disease.

The appropriate dose of Ibuprofen Alkem is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and response to therapy. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety of ibuprofen in pregnancy and lactation depends on the trimester and maternal health. It is generally avoided in the third trimester because of potential fetal cardiovascular effects. Breastfeeding mothers should consult a healthcare provider before use, as ibuprofen does pass into milk in small amounts.

To place an order, submit an enquiry on the Ibuprofen Alkem product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ibuprofen Alkem shares the same mechanism of action as other NSAIDs such as naproxen or diclofenac, offering analgesic, antipyretic and anti‑inflammatory effects. Compared with some alternatives, ibuprofen has a relatively short half‑life, which may require more frequent dosing but often results in a lower incidence of certain gastrointestinal side effects at standard doses.

Ibuprofen Alkem should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture, direct sunlight and excessive heat to maintain potency and stability.

Ibuprofen Alkem is administered orally. The tablet (or other oral dosage form) should be swallowed whole with a full glass of water, preferably with food or milk to reduce potential gastrointestinal irritation.

Serious risks include gastrointestinal bleeding or ulcer perforation, renal impairment, hepatotoxicity, severe allergic reactions such as anaphylaxis, and increased cardiovascular events like myocardial infarction or stroke, especially with high‑dose or prolonged use.

Individuals with known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal ulcer disease, severe renal or hepatic impairment, uncontrolled hypertension, or in the third trimester of pregnancy should avoid using Ibuprofen Alkem unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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