Product image of Ibuprofen Apofri (Ibuprofen) supplied by GNH India

Ibuprofen Apofri

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Apofri (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Apofri, is a nonsteroidal anti-inflammatory drug presented as a strength/form for oral use. It treats pain, fever and inflammation in adults and children when prescribed by a healthcare professional, providing short‑term relief of mild to moderate symptoms.

GNH India supplies Ibuprofen Apofri as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality, regulatory compliance and reliable global distribution.

Manufacturer / TM Owner

Evolan Pharma Ab

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Indications & Clinical Uses

  • Ibuprofen is an NSAID that reduces pain, fever and inflammation by inhibiting prostaglandin synthesis.
  • Pain: provides analgesic relief for mild to moderate acute or chronic pain conditions.
  • Fever: lowers elevated body temperature associated with infectious or inflammatory processes.
  • Inflammation: decreases swelling, redness and discomfort in musculoskeletal or soft‑tissue inflammatory states.

How It Works

  • Ibuprofen reversibly inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, blocking the conversion of arachidonic acid to prostaglandins. Reduced prostaglandin synthesis diminishes peripheral sensitization of nociceptors, lowers the hypothalamic set‑point for temperature, and curtails inflammatory mediators, resulting in analgesic, antipyretic and anti‑inflammatory effects.

Side Effects

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Gastrointestinal discomfort or dyspepsia
  • Nausea or vomiting
  • Headache
  • Dizziness
  • Mild skin rash or itching
  • Transient elevation of liver enzymes

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding
  • Acute renal impairment or failure
  • Severe hypersensitivity reactions, including anaphylaxis
  • Hepatotoxicity with marked enzyme elevation
  • Cardiovascular events such as myocardial infarction or stroke
  • Severe cutaneous adverse reactions (e.g., Stevens‑Johnson syndrome)

Precautions & Warnings

  • Before initiating therapy, consider the following safety measures.
  • Assess renal function: evaluate kidney health, especially in patients with pre‑existing impairment.
  • Monitor gastrointestinal risk: avoid use in individuals with active ulcers or a history of GI bleeding.
  • Use lowest effective dose: limit duration to the shortest period needed for symptom control.
  • Avoid in third‑trimester pregnancy: contraindicated when known due to fetal risks.
  • Check for drug interactions: review all concomitant medications for potential conflicts.
  • Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Ibuprofen can interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Lithium: elevated lithium levels and toxicity.
  • Methotrexate: reduced clearance leading to toxicity.
  • ACE inhibitors or ARBs: possible reduction in renal function.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: may blunt blood‑pressure‑lowering effect.
  • Diuretics: risk of renal insufficiency.
  • SSRIs or SNRIs: heightened bleeding tendency.
  • Corticosteroids: increased risk of GI ulceration.
  • Oral hypoglycemics: potential alteration of glucose control.

Frequently Asked Questions

Ibuprofen Apofri is used to relieve mild to moderate pain, reduce fever, and decrease inflammation associated with conditions such as headache, dental pain, musculoskeletal injuries, and febrile illnesses. It is an oral NSAID prescribed by a healthcare professional for short‑term symptom management.

Ibuprofen works by reversibly inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for converting arachidonic acid into prostaglandins. By lowering prostaglandin levels, it reduces pain signaling, lowers the hypothalamic set‑point for temperature, and diminishes inflammatory swelling.

The appropriate dose of Ibuprofen Apofri is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and response to therapy. Dosage may vary for adults versus children and should follow the prescriber’s instructions and local regulatory guidelines.

Ibuprofen should be used with caution during pregnancy, especially in the third trimester, due to potential fetal risks. It is generally avoided unless clearly needed and prescribed by a physician. While limited data exist for breastfeeding, short‑term use is considered compatible, but a healthcare provider should be consulted.

To order Ibuprofen Apofri, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ibuprofen shares the core mechanism of COX inhibition with other NSAIDs but is often preferred for its balanced analgesic, antipyretic and anti‑inflammatory profile, relatively short half‑life, and well‑characterized safety data. Compared with aspirin, it has less effect on platelet function, and versus stronger NSAIDs like diclofenac, it may have a lower risk of certain cardiovascular events.

Ibuprofen Apofri should be stored at ambient temperature, below 25 °C, in its original container to protect it from moisture, heat and direct sunlight. Keep the product out of reach of children and do not use it after the expiry date printed on the packaging.

Ibuprofen Apofri is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food or milk may reduce gastrointestinal discomfort. The exact administration schedule should follow the prescriber’s directions.

Serious risks include gastrointestinal ulceration or bleeding, acute kidney injury, severe allergic reactions such as anaphylaxis, and increased risk of cardiovascular events like heart attack or stroke, especially with high‑dose or prolonged use. Patients should seek immediate medical attention if they experience signs of these conditions.

Ibuprofen Apofri should be avoided in individuals with known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulcers, severe renal or hepatic impairment, and in the third trimester of pregnancy. It should also be used cautiously in patients on anticoagulants, certain antihypertensives, or other interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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