Product image of Ibuprofen B. Braun (Ibuprofen) supplied by GNH India

Ibuprofen B. Braun

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen B. Braun (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen B. Braun, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an intravenous solution for intravenous use. It is employed to treat mild to moderate pain, postoperative discomfort, fever, and various inflammatory conditions in adult patients, including surgical and emergency settings.

GNH India supplies Ibuprofen B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, including tertiary care centers and acute care facilities across multiple continents. The company adheres to stringent quality standards and provides regulatory documentation for import and distribution.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

  • Ibuprofen administered intravenously acts as an NSAID to reduce pain, fever, and inflammation.
  • Mild to moderate pain: provides rapid analgesia for acute surgical or trauma‑related discomfort.
  • Post‑operative pain: helps control pain after surgical procedures, facilitating early mobilization.
  • Fever: lowers elevated body temperature in hospitalized patients.
  • Inflammatory conditions: diminishes inflammation in acute settings such as musculoskeletal injuries.

How It Works

  • Ibuprofen exerts its effect by reversibly inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis decreases peripheral sensitization of nociceptors, lowers the hypothalamic set‑point for temperature, and limits inflammatory exudate formation, resulting in analgesic, antipyretic, and anti‑inflammatory actions.

Side Effects

Intravenous ibuprofen may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: transient feeling of sickness that may resolve without intervention.
  • Headache: mild to moderate pain in the head region.
  • Injection site pain: discomfort at the site of intravenous administration.

Serious or Rare Side Effects

  • Gastrointestinal bleeding: potentially life‑threatening hemorrhage in the digestive tract.
  • Acute renal failure: sudden loss of kidney function, especially in patients with pre‑existing renal disease.
  • Anaphylaxis: severe, rapid‑onset allergic reaction that can be fatal if not treated promptly.

Precautions & Warnings

  • When using intravenous ibuprofen, clinicians should observe several safety measures.
  • Assess renal function: evaluate baseline creatinine before initiation.
  • Monitor gastrointestinal risk: avoid in patients with active ulcer disease.
  • Use caution with cardiovascular disease: NSAIDs may increase thrombotic risk.
  • Avoid in known hypersensitivity to ibuprofen or other NSAIDs.
  • Review concomitant anticoagulant therapy: increased bleeding risk.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ibuprofen can interact with several medication classes; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Lithium: increased serum lithium concentrations.
  • Methotrexate: reduced renal clearance leading to toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible decline in renal function.
  • Diuretics: risk of volume depletion and renal impairment.
  • SSRIs or SNRIs: additive bleeding tendency.

Frequently Asked Questions

Ibuprofen B. Braun is an intravenous formulation of ibuprofen used in hospital settings to provide rapid relief of mild to moderate pain, control postoperative discomfort, reduce fever, and manage acute inflammatory conditions such as musculoskeletal injuries.

Ibuprofen works by reversibly inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which blocks the synthesis of prostaglandins. Lower prostaglandin levels decrease pain signaling, lower the hypothalamic temperature set‑point, and reduce inflammation at the site of injury.

The specific dose and infusion rate are determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and therapeutic goals. Healthcare professionals follow local guidelines and product labeling to select an appropriate regimen.

Safety data for intravenous ibuprofen in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician in consultation with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and the necessary import documentation.

Compared with alternatives such as ketorolac injection, intravenous ibuprofen offers a similar analgesic and antipyretic profile but may have a slightly lower risk of renal adverse effects at equivalent doses. Choice of agent depends on individual patient factors, institutional protocols, and cost considerations.

The product must be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Prior to use, inspect the solution for particulate matter or discoloration and follow aseptic techniques during preparation and administration.

Ibuprofen B. Braun is given by intravenous infusion. The solution is typically diluted in compatible IV fluids and infused over a period of 15‑30 minutes, depending on the prescribed dose and the patient’s clinical status. Administration should be performed by qualified healthcare personnel.

The most serious adverse events include gastrointestinal bleeding, acute renal failure, and severe allergic reactions such as anaphylaxis. Prompt recognition and management of these events are essential, and patients should be monitored closely, especially if they have pre‑existing risk factors.

Patients with known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulcer disease, severe renal impairment, uncontrolled heart failure, or those receiving anticoagulant therapy with a high bleeding risk should avoid this product unless a clinician determines that benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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