Product image of Ibuprofen B. Braun (Ibuprofen) supplied by GNH India

Ibuprofen B. Braun

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen B. Braun (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen B. Braun, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as a intravenous solution for intravenous use. It treats mild to moderate pain, postoperative pain, fever, and inflammatory conditions in hospitalized patients.

GNH India supplies Ibuprofen B. Braun as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

  • Ibuprofen is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.
  • Mild to moderate pain: provides analgesia to relieve discomfort.
  • Post‑operative pain: helps control pain after surgical procedures.
  • Fever: reduces elevated body temperature.
  • Inflammatory conditions: diminishes swelling and inflammation associated with conditions such as rheumatoid arthritis.

How It Works

  • Ibuprofen non‑selectively inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis reduces peripheral sensitization, inflammation, and the hypothalamic set‑point for temperature, thereby providing analgesic, antipyretic, and anti‑inflammatory effects.

Side Effects

Adverse reactions may occur with any intravenous NSAID and should be monitored.

Common Side Effects

  • Nausea or vomiting
  • Headache
  • Dizziness
  • Injection‑site pain or erythema

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration
  • Acute renal impairment or failure
  • Severe hypersensitivity reactions including anaphylaxis
  • Thrombotic cardiovascular events such as myocardial infarction or stroke

Precautions & Warnings

  • Use ibuprofen intravenously only when benefits outweigh potential risks and under appropriate medical supervision.
  • Renal function: assess baseline renal status and monitor renal parameters during therapy.
  • Bleeding risk: avoid in patients with active gastrointestinal ulceration or coagulopathy.
  • Cardiovascular risk: use cautiously in patients with known coronary artery disease or uncontrolled hypertension.
  • Pregnancy: avoid unless the potential benefit justifies the potential risk to the fetus.
  • Drug interactions: review concomitant use of other NSAIDs, anticoagulants, or nephrotoxic agents.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ibuprofen may interact with several drug classes, requiring careful assessment before co‑administration.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in renal function.
  • Loop diuretics: heightened risk of renal impairment.
  • Lithium: ibuprofen can raise serum lithium concentrations.
  • Methotrexate: reduced clearance may lead to toxicity.

Frequently Asked Questions

Ibuprofen B. Braun is an intravenous formulation of ibuprofen indicated for the management of mild to moderate pain, postoperative pain, fever, and inflammatory conditions such as rheumatoid arthritis in a hospital setting. It is administered by healthcare professionals to provide rapid analgesic, antipyretic, and anti‑inflammatory effects.

Ibuprofen works by non‑selectively inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for converting arachidonic acid into prostaglandins. By reducing prostaglandin synthesis, ibuprofen decreases inflammation, lowers the pain‑signal threshold, and resets the hypothalamic temperature set‑point, resulting in analgesic, anti‑inflammatory, and antipyretic actions.

The appropriate dose of Ibuprofen B. Braun is determined by the prescribing clinician based on the patient’s condition, weight, renal function, and other clinical factors. Healthcare providers follow local guidelines and product labeling to select the correct infusion rate and total daily amount.

Safety data for intravenous ibuprofen during pregnancy are limited, and the product is generally avoided unless the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should consult their healthcare provider, as ibuprofen can be excreted in breast milk and may affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics if needed), and any required import documentation.

Ibuprofen B. Braun offers a well‑characterized safety profile and is often chosen for its balanced analgesic and antipyretic effects. Compared with ketorolac, another IV NSAID, ibuprofen generally has a lower risk of severe gastrointestinal bleeding but may require higher doses for equivalent analgesia. Choice depends on patient‑specific factors, including renal function and bleeding risk.

The product must be stored at 2‑8 °C in a refrigerator, protected from light, and should never be frozen or shaken. Before administration, inspect the solution for particulate matter or discoloration. Use aseptic technique and follow institutional protocols for IV infusion.

Ibuprofen B. Braun is given as an intravenous infusion, typically diluted in compatible IV fluids and administered over a specified period as directed by the prescriber. The infusion rate and total daily dose are adjusted according to the patient’s clinical response and tolerability.

Serious adverse events include gastrointestinal bleeding or ulceration, acute renal failure, severe hypersensitivity reactions such as anaphylaxis, and thrombotic cardiovascular events like myocardial infarction or stroke. Patients should be monitored closely for signs of bleeding, renal dysfunction, or allergic reactions during therapy.

Ibuprofen B. Braun is contraindicated in patients with known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulceration or bleeding, severe uncontrolled hypertension, advanced heart failure, and those with significant renal impairment. It should also be avoided in patients receiving certain anticoagulants unless the benefit outweighs the risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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