Product image of Ibuprofen B. Braun (Ibuprofen) supplied by GNH India

Ibuprofen B. Braun

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen B. Braun (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen B. Braun, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an injectable solution for intravenous use. It provides analgesic, antipyretic and anti‑inflammatory effects for the treatment of pain, fever and postoperative inflammation in hospitalized patients and can be administered under controlled clinical settings as part of multimodal analgesia protocols.

GNH India supplies Ibuprofen B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide and collaborates with procurement teams to ensure timely delivery, regulatory compliance and product quality across global markets.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

  • Ibuprofen, an NSAID, reduces inflammation and pain by inhibiting cyclooxygenase enzymes.
  • Pain: provides analgesia for acute moderate to severe pain
  • Fever: lowers elevated body temperature in febrile states
  • Inflammation: diminishes inflammatory response in musculoskeletal conditions
  • Post‑operative pain: manages pain following surgical procedures

How It Works

  • Ibuprofen exerts its effect by non‑selectively inhibiting the cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which catalyze the conversion of arachidonic acid to prostaglandins and thromboxanes. The reduction in prostaglandin synthesis leads to decreased sensitisation of nociceptors, a lower fever set‑point in the hypothalamus and diminished vascular permeability, thereby providing analgesic, antipyretic and anti‑inflammatory actions.

Side Effects

Adverse reactions to intravenous ibuprofen may range from mild to severe.

Common Side Effects

  • Nausea
  • Dyspepsia
  • Headache
  • Dizziness
  • Injection‑site pain
  • Mild hypotension

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration
  • Acute renal impairment
  • Severe hypersensitivity reactions including anaphylaxis
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Thrombocytopenia
  • Hepatic failure

Precautions & Warnings

  • When using intravenous ibuprofen, clinicians should consider several safety measures.
  • Renal function: assess baseline renal status and monitor during therapy
  • Cardiovascular risk: use cautiously in patients with hypertension or heart failure
  • Gastro‑intestinal history: avoid in active ulcer disease or recent GI bleeding
  • Bleeding risk: evaluate concomitant anticoagulant or antiplatelet therapy
  • Pregnancy: reserve for situations where benefits outweigh potential risks
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake

Avoid Interactions

Ibuprofen may interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin, heparin): increased risk of bleeding
  • ACE inhibitors or ARBs: potential reduction in renal function
  • Lithium: elevated lithium serum concentrations

Moderate Interactions (Monitor Closely)

  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency
  • Corticosteroids: additive gastrointestinal irritation
  • Loop diuretics: possible impact on renal clearance

Frequently Asked Questions

Ibuprofen B. Braun is an intravenous formulation of ibuprofen used in hospital settings to provide rapid analgesic, antipyretic and anti‑inflammatory effects. It is commonly employed for the relief of moderate to severe pain, reduction of fever, and control of inflammation after surgical procedures or traumatic injuries.

Ibuprofen works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for converting arachidonic acid into prostaglandins. By lowering prostaglandin levels, it reduces pain‑signal sensitisation, lowers the hypothalamic set‑point for temperature, and diminishes inflammatory swelling and redness.

The specific dose of Ibuprofen B. Braun is determined by the prescribing clinician based on the patient’s age, weight, clinical condition and therapeutic goals. Healthcare professionals follow local guidelines and product labeling to select an appropriate intravenous dose and infusion rate.

Safety data for intravenous ibuprofen in pregnancy are limited, and the product does not have a definitive pregnancy category. It should only be used when the potential benefit justifies the possible risk to the fetus. Breastfeeding mothers should consult a physician, as ibuprofen can be excreted in milk.

To place an order, visit the product page on gnhindia.com, enter the required quantity and submit the enquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed) and any required import documentation.

Both ibuprofen and ketorolac are NSAIDs that inhibit COX enzymes, but ketorolac is generally considered more potent for short‑term postoperative pain and carries a higher risk of renal and gastrointestinal adverse effects. Ibuprofen offers a broader therapeutic window and is often preferred when a balance between efficacy and safety is desired, especially in patients with moderate renal risk.

Ibuprofen B. Braun must be stored refrigerated at 2 °C to 8 °C. The solution should be kept in its original container, protected from light, and must not be frozen or shaken. Before administration, inspect the vial for particulate matter and ensure it is at the appropriate temperature.

The product is given by intravenous infusion. It is typically diluted in a compatible IV fluid and administered over a period defined by the prescribing information, often 15–30 minutes. Administration should be performed by qualified healthcare personnel in a setting equipped for intravenous therapy.

Serious risks include gastrointestinal bleeding or ulceration, acute renal impairment, severe hypersensitivity reactions such as anaphylaxis, and rare but life‑threatening skin reactions like Stevens‑Johnson syndrome. Patients should be monitored for signs of bleeding, changes in urine output, rash, or respiratory distress during and after infusion.

Ibuprofen B. Braun is contraindicated in patients with known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulceration or bleeding, severe renal or hepatic impairment, and in those who have experienced a previous severe reaction to an intravenous NSAID. Caution is also advised in patients with uncontrolled hypertension or heart failure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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