Ibuprofen B. Braun (Ibuprofen)

Ibuprofen injection is an NSAID that reduces prostaglandin‑mediated inflammation and is indicated for several acute conditions.

• Pain: provides analgesia for postoperative or trauma‑related pain.
• Fever: lowers elevated body temperature in febrile patients.
• Inflammation: diminishes inflammatory response in musculoskeletal injury and other acute inflammatory states.

• Ibuprofen inhibits both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, leading to decreased synthesis of prostaglandins that mediate pain, fever, and inflammation. By reducing prostaglandin levels at sites of tissue injury, it attenuates nociceptor sensitization and the febrile response, while also limiting vascular permeability and leukocyte infiltration.

Intravenous ibuprofen may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

• Nausea: mild to moderate upset stomach.
• Headache: transient cranial discomfort.
• Dizziness: occasional light‑headedness.
• Injection site pain: local discomfort at the venipuncture site.
• Mild hypertension: temporary rise in blood pressure.
• Transient renal function changes: slight increase in serum creatinine.

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration.
• Severe renal impairment or acute kidney injury.
• Anaphylaxis: life‑threatening allergic reaction.
• Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Cardiovascular thrombotic events (e.g., myocardial infarction, stroke).
• Hepatotoxicity: marked elevation of liver enzymes.

When using intravenous ibuprofen, clinicians should observe several safety considerations to minimize risk.

• Renal function: assess baseline and monitor serum creatinine during therapy.
• Gastrointestinal risk: evaluate history of ulcer disease or bleeding before administration.
• Cardiovascular disease: use caution in patients with heart failure or ischemic heart disease.
• Hypersensitivity: avoid in individuals with known ibuprofen or NSAID allergy.
• Concomitant anticoagulants: monitor for increased bleeding tendency.
• Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake the vial.

Ibuprofen can affect the pharmacodynamics or pharmacokinetics of other medicines; interactions are grouped by clinical significance.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• Lithium: ibuprofen may raise serum lithium concentrations, risking toxicity.
• Methotrexate: reduced clearance can lead to methotrexate toxicity.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: combined use may impair renal function.
• Diuretics: potential for electrolyte disturbances and reduced renal perfusion.
• SSRIs: additive effect on platelet inhibition, raising bleeding risk.
• Corticosteroids: heightened risk of gastrointestinal ulceration and bleeding.