Product image of Ibuprofen B. Braun (Ibuprofen) supplied by GNH India

Ibuprofen B. Braun

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen B. Braun (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen B. Braun, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as an intravenous solution for intravenous use. Approved in the European Union, it treats mild to moderate pain, postoperative pain, fever, and inflammatory conditions in hospital patients.

GNH India supplies Ibuprofen B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and clinics worldwide.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

  • Ibuprofen is an NSAID that reduces pain, fever, and inflammation by inhibiting prostaglandin synthesis.
  • Mild to moderate pain: provides analgesia for acute or postoperative pain
  • Fever: lowers elevated body temperature
  • Inflammatory conditions: reduces swelling and discomfort in disorders such as arthritis

How It Works

  • Ibuprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which are key in the conversion of arachidonic acid to prostaglandins. By decreasing prostaglandin production, it diminishes peripheral sensitisation of nociceptors, reduces fever‑inducing hypothalamic signaling, and limits inflammatory exudate formation. The inhibition is dose‑dependent and reversible, allowing rapid onset when administered intravenously, and supports its use in acute care where quick analgesia and antipyresis are required.

Side Effects

Adverse reactions to intravenous ibuprofen can range from mild to serious and should be monitored during therapy.

Common Side Effects

  • Injection site pain: mild discomfort at the infusion site
  • Nausea: feeling of queasiness
  • Dyspepsia: upset stomach or indigestion
  • Headache: mild to moderate head pain

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction with airway compromise
  • Renal impairment: acute kidney injury especially in volume‑depleted patients
  • Gastrointestinal bleeding: ulceration or hemorrhage in the stomach or intestines

Precautions & Warnings

When using intravenous ibuprofen, clinicians should observe several safety precautions to minimise risk.

  • Renal function: assess baseline kidney function and avoid use in severe renal impairment
  • Bleeding risk: avoid in patients with active gastrointestinal ulcer or coagulopathy
  • Cardiovascular disease: use cautiously in patients with heart failure or coronary artery disease
  • Pregnancy: contraindicated in the third trimester and should be avoided unless benefit outweighs risk
  • Drug interactions: review concomitant medications, especially other NSAIDs, anticoagulants, and ACE inhibitors
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake

Avoid Interactions

Ibuprofen may interact with several medicines; understanding the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency
  • ACE inhibitors or ARBs in patients with renal insufficiency: may worsen kidney function

Moderate Interactions (Monitor Closely)

  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity
  • Diuretics: may reduce renal perfusion when combined
  • Lithium: ibuprofen can raise lithium serum concentrations

Frequently Asked Questions

Ibuprofen B. Braun is an intravenous formulation of ibuprofen used in hospital settings to provide rapid relief of mild to moderate pain, control postoperative discomfort, reduce fever, and manage inflammatory conditions such as acute arthritis or tissue inflammation.

Ibuprofen works by non‑selectively inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which blocks the conversion of arachidonic acid into prostaglandins. Lower prostaglandin levels decrease inflammation, lower fever, and reduce the sensitisation of pain receptors, producing analgesic and antipyretic effects.

The specific dose and infusion rate of Ibuprofen B. Braun are determined by the prescribing clinician based on the patient’s condition, weight, renal function, and other clinical factors. Healthcare professionals should follow local prescribing guidelines and the product’s prescribing information.

The pregnancy category for this intravenous ibuprofen product is not established. Generally, NSAIDs are avoided in the third trimester because of potential fetal complications, and they should be used during pregnancy only when the benefit justifies the risk. Breastfeeding mothers should consult a physician before use.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and any necessary import documentation.

Compared with oral NSAIDs, the intravenous form offers faster onset and more predictable plasma levels, which is advantageous in acute care. Unlike opioids, ibuprofen provides analgesia without respiratory depression, but it shares the typical NSAID risks of gastrointestinal bleeding, renal effects, and platelet inhibition.

The product must be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Before administration, inspect the solution for particulate matter or discoloration and allow it to reach room temperature if required by the infusion protocol.

Ibuprofen B. Braun is given by intravenous infusion. The healthcare professional selects an appropriate infusion set, dilutes the solution if required by the label, and administers it over the recommended time period, usually under continuous monitoring for adverse reactions.

Serious risks include anaphylactic reactions, acute renal impairment, and gastrointestinal bleeding or ulceration. Patients should be monitored for signs of allergic response, sudden changes in urine output, or unexplained abdominal pain or bleeding during and after infusion.

Contraindications include patients with known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulceration or bleeding, severe renal or hepatic impairment, uncontrolled heart failure, and those in the third trimester of pregnancy unless the benefit outweighs the risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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