Product image of Ibuprofen B. Braun (Ibuprofen) supplied by GNH India

Ibuprofen B. Braun

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen B. Braun (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen B. Braun, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an intravenous solution for intravenous use. It is employed in the management of mild to moderate pain, fever, inflammation, post‑operative discomfort and musculoskeletal pain, primarily in hospital settings across the European Union. The formulation provides rapid systemic exposure, allowing clinicians to achieve timely analgesia and antipyretic effect in acute care environments.

GNH India supplies Ibuprofen B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, clinics and procurement teams worldwide, ensuring quality and regulatory conformity for intravenous medicines.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

Ibuprofen, an NSAID, reduces pain, fever and inflammation by inhibiting cyclooxygenase enzymes.

  • Mild to moderate pain: Provides analgesia for acute or postoperative pain.
  • Fever: Lowers elevated body temperature in febrile patients.
  • Inflammation: Decreases swelling and local inflammatory response.
  • Post‑operative pain: Controls discomfort after surgical procedures.
  • Musculoskeletal pain: Relieves pain associated with strains, sprains and other musculoskeletal injuries.
  • Acute inflammatory conditions: Helps manage rapid onset inflammatory episodes.

How It Works

  • Ibuprofen non‑selectively inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes peripheral sensitisation of nociceptors, lowers the hypothalamic set‑point for temperature regulation, and curtails inflammatory mediators, resulting in analgesic, antipyretic and anti‑inflammatory effects.

Side Effects

Adverse reactions may occur with intravenous ibuprofen administration.

Common Side Effects

  • Nausea: Mild to moderate feeling of stomach upset.
  • Vomiting: Involuntary expulsion of gastric contents.
  • Headache: Transient cranial discomfort.
  • Dizziness: Light‑headed sensation or imbalance.
  • Injection site pain: Local discomfort at the infusion site.

Serious or Rare Side Effects

  • Gastrointestinal bleeding: May present as melena or hematemesis.
  • Renal impairment: Sudden decrease in kidney function, especially in at‑risk patients.
  • Anaphylaxis: Severe allergic reaction with rash, bronchospasm, or hypotension.

Precautions & Warnings

Careful assessment and monitoring are required when using intravenous ibuprofen.

  • Renal function: Evaluate baseline renal status and avoid use in severe impairment.
  • Cardiovascular risk: Use cautiously in patients with known heart disease or hypertension.
  • Gastrointestinal history: Avoid in individuals with active ulcers or recent GI bleeding.
  • Concomitant anticoagulants: Monitor for increased bleeding risk when combined with anticoagulant therapy.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ibuprofen may interact with several drug classes, necessitating vigilance.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): Heightened risk of serious bleeding.
  • High‑dose aspirin: Increased gastrointestinal toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: May reduce renal perfusion, especially in dehydrated patients.
  • Diuretics: Potential for additive renal function decline.
  • Lithium: Ibuprofen can raise serum lithium levels, requiring monitoring.

Frequently Asked Questions

Ibuprofen B. Braun is an intravenous formulation of ibuprofen used in hospital settings to treat mild to moderate pain, reduce fever, and control inflammation associated with conditions such as postoperative discomfort, musculoskeletal injuries, and acute inflammatory episodes.

Ibuprofen works by non‑selectively inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which blocks the synthesis of prostaglandins. Lower prostaglandin levels reduce pain signalling, lower fever by acting on the hypothalamus, and diminish inflammation at the site of injury.

The specific dose of Ibuprofen B. Braun is determined by the prescribing clinician based on the patient’s condition, weight, renal function and other clinical factors. Healthcare professionals follow local guidelines and product labeling to set the appropriate infusion rate and total amount.

Safety data for intravenous ibuprofen during pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used when the potential benefit justifies any possible risk, and a healthcare provider should evaluate each case individually.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Compared with other intravenous NSAIDs such as ketorolac, ibuprofen offers a similar analgesic and antipyretic profile but may have a slightly lower risk of renal toxicity at equivalent doses. Choice between agents depends on the clinical scenario, patient comorbidities, and institutional protocols.

Ibuprofen B. Braun should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Before administration, the solution should be inspected for particulate matter and used within the time frame recommended by the manufacturer after removal from controlled storage.

The product is given by intravenous infusion under the supervision of qualified healthcare personnel. It is typically diluted in an appropriate compatible IV fluid and administered over a prescribed period, following aseptic technique and the infusion guidelines provided in the product’s prescribing information.

Serious risks include gastrointestinal bleeding, acute renal failure, hypersensitivity reactions such as anaphylaxis, and cardiovascular events like myocardial infarction or stroke, especially in patients with pre‑existing risk factors. Prompt recognition and medical intervention are essential if any of these events occur.

Patients with known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulceration or bleeding, severe renal or hepatic impairment, and those receiving certain anticoagulants without close monitoring should avoid using Ibuprofen B. Braun unless a clinician determines that benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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