Product image of Ibuprofen B. Braun (Ibuprofen) supplied by GNH India

Ibuprofen B. Braun

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen B. Braun (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen B. Braun, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an intravenous solution for intravenous use. It treats pain, fever and inflammation, including postoperative pain, in adult patients, and is commonly employed in surgical and emergency care settings. Administration is performed under professional supervision in a controlled clinical environment.

GNH India supplies Ibuprofen B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, clinics and procurement teams worldwide, ensuring quality, regulatory compliance and reliable delivery across multiple markets.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

  • Ibuprofen administered intravenously acts on the cyclooxygenase pathway to relieve several acute conditions.
  • Pain: Provides rapid analgesia for moderate to severe acute pain.
  • Fever: Reduces elevated body temperature in febrile states.
  • Inflammation: Decreases inflammatory response in acute tissue injury.
  • Postoperative pain: Controls pain following surgical procedures.

How It Works

  • Ibuprofen reversibly inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, leading to reduced synthesis of prostaglandins that mediate pain, fever, and inflammation. By lowering prostaglandin levels at sites of tissue injury, it diminishes nociceptor sensitization and the febrile response, providing analgesic, antipyretic, and anti‑inflammatory effects.

Side Effects

Intravenous ibuprofen may be associated with a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Nausea or vomiting
  • Headache
  • Dizziness or light‑headedness
  • Injection‑site pain or erythema
  • Transient elevation of liver enzymes

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration
  • Acute renal impairment or failure
  • Severe hypersensitivity reactions, including anaphylaxis
  • Thrombocytopenia or bleeding disorders
  • Hepatic failure or severe liver injury

Precautions & Warnings

Use of intravenous ibuprofen requires careful assessment of patient‑specific factors.

  • Renal function: Evaluate baseline kidney function and avoid use in severe renal impairment.
  • Hepatic function: Monitor liver enzymes, especially in patients with existing liver disease.
  • Bleeding risk: Use cautiously in patients with active bleeding or on anticoagulants.
  • Pregnancy: Category C; avoid in the third trimester and discuss risks with a physician.
  • Concomitant NSAIDs: Do not combine with other NSAIDs or aspirin without medical guidance.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake the solution.

Avoid Interactions

Ibuprofen can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): Increased risk of serious bleeding.
  • ACE inhibitors or ARBs: May reduce renal perfusion and precipitate renal failure.
  • Lithium: NSAIDs can raise lithium levels, risking toxicity.

Moderate Interactions (Monitor Closely)

  • Methotrexate: Reduced clearance may increase toxicity.
  • Diuretics: Potential for reduced renal function.
  • Corticosteroids: Additive risk of gastrointestinal ulceration.
  • SSRIs: May modestly increase bleeding tendency.
  • Oral hypoglycemics: May enhance hypoglycemic effect.

Frequently Asked Questions

Ibuprofen B. Braun is an intravenous formulation of ibuprofen used in hospitals to provide rapid relief of moderate to severe pain, reduce fever, and control inflammation, particularly after surgery or in acute care settings where oral administration is not feasible.

Ibuprofen blocks the activity of cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for producing prostaglandins. By lowering prostaglandin levels, it diminishes pain signaling, reduces fever, and limits the inflammatory response at the site of tissue injury.

The appropriate dose of intravenous ibuprofen is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and renal or hepatic function. Dosage regimens are individualized and should follow the prescriber’s instructions.

Ibuprofen is classified as Pregnancy Category C, meaning risk cannot be ruled out. It should be avoided in the third trimester and used only if the potential benefit justifies the risk. Limited data are available for breastfeeding; a healthcare professional should evaluate safety for mother and infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Both ibuprofen and ketorolac are injectable NSAIDs that provide analgesia and antipyresis. Ibuprofen generally has a slightly longer half‑life and a broader safety margin for gastrointestinal effects, while ketorolac is often considered more potent for short‑term postoperative pain but carries a higher risk of renal toxicity at comparable doses.

The product must be stored refrigerated at 2 °C to 8 °C, protected from light, and must not be frozen or shaken. Before use, inspect the solution for particulate matter or discoloration and administer only with aseptic technique in a clinical setting.

Ibuprofen B. Braun is given as an intravenous infusion, typically over 15–30 minutes, under the supervision of qualified healthcare personnel. The infusion rate and total daily dose are set by the prescriber, and the medication is administered using sterile equipment in a monitored environment.

Serious risks include gastrointestinal bleeding or ulceration, acute kidney injury, severe hypersensitivity reactions such as anaphylaxis, and rare cases of hepatic failure. Patients should be monitored for signs of bleeding, renal dysfunction, or allergic reactions during and after infusion.

Contraindications include known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulcer or bleeding, severe renal or hepatic impairment, third‑trimester pregnancy, and patients receiving certain anticoagulants without close monitoring. Clinicians should assess each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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