Ibuprofen Bruis Teva (Ibuprofen)

Ibuprofen is an NSAID that reduces prostaglandin-mediated inflammation and is used for several common conditions.

• Pain: provides analgesic relief for mild to moderate pain.
• Fever: lowers elevated body temperature.
• Inflammation: decreases swelling associated with musculoskeletal disorders.
• Headache: alleviates tension‑type headaches.
• Dental pain: manages postoperative dental discomfort.

• Ibuprofen exerts its effect by non‑selectively inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2, which catalyze the conversion of arachidonic acid to prostaglandins. By reducing prostaglandin synthesis, it decreases inflammation, pain signaling, and the hypothalamic set‑point for temperature, resulting in analgesic, antipyretic, and anti‑inflammatory actions. The inhibition is reversible and occurs throughout peripheral tissues and the central nervous system.

Ibuprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

• Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
• Headache: mild to moderate intensity.
• Dizziness: transient sensation of light‑headedness.
• Rash: mild skin irritation or erythema.
• Diarrhea: loose stools without blood.
• Elevated blood pressure: slight increase in some patients.

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulcer perforation.
• Renal impairment or acute kidney injury.
• Hepatic injury with elevated liver enzymes.
• Severe allergic reactions such as anaphylaxis.
• Cardiovascular events including thrombotic complications.
• Blood dyscrasias such as thrombocytopenia.

When using Ibuprofen, consider the following precautions to minimize risk.

• Assess renal function: monitor kidney parameters in patients with pre‑existing renal disease.
• Evaluate gastrointestinal risk: avoid in patients with active ulcer disease or a history of GI bleeding.
• Consider cardiovascular status: use cautiously in patients with hypertension or heart disease.
• Pregnancy and lactation: discuss risks with a healthcare provider before use.
• Drug interactions: review concomitant medications for potential NSAID interactions.
• Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Ibuprofen can interact with several medicines; awareness of major and moderate interactions helps ensure safe use.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• SSRIs: heightened gastrointestinal bleeding.
• Lithium: increased serum lithium concentrations.

Moderate Interactions (Monitor Closely)

• ACE inhibitors/ARBs: may reduce renal perfusion.
• Corticosteroids: additive risk of gastric ulceration.
• Diuretics: potential for reduced renal function.