Product image of Ibuprofen Dermogen (Ibuprofen) supplied by GNH India

Ibuprofen Dermogen

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Dermogen (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Dermogen, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It treats mild to moderate pain, fever, and inflammatory conditions such as arthritis in adults.

GNH India supplies Ibuprofen Dermogen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Dermogen Farma, S.A.

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Indications & Clinical Uses

Ibuprofen acts systemically to reduce pain, fever, and inflammation associated with several common conditions.

  • Mild to moderate pain: provides analgesia for headaches, dental pain, musculoskeletal discomfort, and postoperative pain.
  • Fever: lowers elevated body temperature in febrile states.
  • Inflammatory arthritis: diminishes joint swelling and stiffness in osteoarthritis and rheumatoid arthritis.

How It Works

  • Ibuprofen reversibly inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, reducing the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels decrease peripheral sensitisation of nociceptors, lower fever set‑point in the hypothalamus, and limit inflammatory exudate formation, resulting in analgesic, antipyretic, and anti‑inflammatory effects.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or mild abdominal pain.
  • Headache: transient mild headache.
  • Dizziness: occasional light‑headedness.
  • Rash: mild skin erythema or itching.
  • Elevated liver enzymes: mild, reversible increase.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Renal impairment: reduced kidney function or acute failure.
  • Severe hypersensitivity: anaphylaxis, Stevens‑Johnson syndrome.
  • Cardiovascular events: increased risk of myocardial infarction or stroke.
  • Hepatotoxicity: significant liver injury.

Precautions & Warnings

Before using Ibuprofen, consider the following safety measures.

  • Assess renal function: avoid use in patients with severe renal impairment.
  • Evaluate gastrointestinal risk: use cautiously in those with a history of ulcers or bleeding.
  • Monitor cardiovascular status: limit use in patients with established heart disease.
  • Review concomitant medications: avoid combining with other NSAIDs or anticoagulants without supervision.
  • Pregnancy and lactation: discuss risks with a healthcare professional before use.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Selective COX‑2 inhibitors: additive gastrointestinal toxicity.
  • High‑dose aspirin: enhanced renal impairment.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in antihypertensive effect.
  • Diuretics: potential decrease in renal perfusion.
  • Lithium: increased lithium levels.
  • Methotrexate: reduced clearance leading to toxicity.

Frequently Asked Questions

Ibuprofen Dermogen is indicated for the relief of mild to moderate pain, reduction of fever, and management of inflammatory conditions such as osteoarthritis and rheumatoid arthritis. It is commonly prescribed when a non‑opioid analgesic and anti‑inflammatory agent is needed.

Ibuprofen blocks the activity of cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for the synthesis of prostaglandins. By lowering prostaglandin levels, it reduces the sensitisation of pain receptors, lowers the hypothalamic set‑point for temperature, and diminishes the inflammatory response in tissues.

The appropriate dose of Ibuprofen Dermogen is determined by the prescribing clinician based on the patient’s age, weight, severity of symptoms, and overall health status. Dosage instructions are provided on the prescription label and should be followed exactly as directed.

Safety of ibuprofen during pregnancy and lactation depends on the trimester and individual risk factors. It is generally avoided in the third trimester because of potential fetal cardiovascular effects, and a healthcare professional should evaluate the benefit‑risk balance before prescribing it to pregnant or nursing mothers.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Ibuprofen shares a similar mechanism of action with other non‑steroidal anti‑inflammatory drugs such as naproxen and diclofenac, but it differs in pharmacokinetic profile, dosing frequency, and individual tolerability. Clinicians may choose ibuprofen for its relatively short half‑life and established safety record in short‑term use.

Ibuprofen Dermogen should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, heat, and direct sunlight, and ensure the package is tightly closed to maintain product stability.

Ibuprofen Dermogen is taken orally with a full glass of water. It can be taken with or without food; however, taking it with food or milk may reduce the likelihood of gastrointestinal discomfort. Swallow the tablet whole; do not crush or chew unless instructed by a healthcare professional.

Serious adverse events include gastrointestinal bleeding or ulceration, severe allergic reactions such as anaphylaxis, renal impairment, and increased risk of cardiovascular events like heart attack or stroke, especially with high‑dose or prolonged use. Patients should seek immediate medical attention if they experience any of these symptoms.

Individuals with a known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal ulcers, severe renal or hepatic impairment, uncontrolled hypertension, or a history of cardiovascular disease should avoid using Ibuprofen Dermogen unless a physician determines that the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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