Product image of Ibuprofen Dolorgiet 400 Mg Weichkapseln (Ibuprofen) supplied by GNH India

Ibuprofen Dolorgiet 400 Mg Weichkapseln

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Dolorgiet 400 Mg Weichkapseln (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Dolorgiet 400 Mg Weichkapseln, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as a 400 mg soft gelatin capsule for oral use. It provides analgesic, antipyretic and anti‑inflammatory effects for the relief of mild to moderate pain, fever and inflammatory conditions in adults and adolescents.

GNH India supplies Ibuprofen Dolorgiet 400 Mg Weichkapseln as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches for global distribution.

Manufacturer / TM Owner

Dolorgiet Gmbh & Co Kg

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Indications & Clinical Uses

Ibuprofen acts as an NSAID to reduce pain, fever and inflammation across several common conditions.

  • Mild to moderate pain: provides analgesic relief for headaches, dental pain, musculoskeletal discomfort.
  • Fever: lowers elevated body temperature associated with infections or inflammatory states.
  • Osteoarthritis: reduces joint pain and improves function in chronic degenerative disease.
  • Rheumatoid arthritis: alleviates inflammatory joint pain and swelling.
  • Dysmenorrhea: eases menstrual cramps and associated discomfort.

How It Works

  • Ibuprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which are essential for the conversion of arachidonic acid to prostaglandins. By decreasing prostaglandin synthesis, it reduces peripheral sensitisation of nociceptors, lowers the hypothalamic set‑point for temperature, and diminishes inflammatory mediators, resulting in analgesic, antipyretic and anti‑inflammatory actions.

Side Effects

Ibuprofen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness: transient sensation of light‑headedness.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding: potentially severe GI tract injury.
  • Renal impairment: reduced kidney function or acute kidney injury.
  • Severe hypersensitivity: anaphylaxis or angioedema.

Precautions & Warnings

When using ibuprofen, several precautions should be observed to minimise risk and ensure safe therapy.

  • Assess renal function: evaluate kidney health before initiating therapy, especially in patients with pre‑existing renal disease.
  • Monitor gastrointestinal risk: consider ulcer history and co‑prescribed NSAIDs or anticoagulants.
  • Check cardiovascular status: use cautiously in patients with hypertension, heart failure or established cardiovascular disease.
  • Review concomitant medications: avoid use with other COX‑inhibitors, certain antihypertensives, or lithium.
  • Pregnancy and lactation: discuss risks with a healthcare professional before use during pregnancy or breastfeeding.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Antiplatelet agents (e.g., clopidogrel): additive antiplatelet effect raising hemorrhage potential.
  • Selective COX‑2 inhibitors: heightened gastrointestinal toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce antihypertensive effect and impair renal function.
  • Diuretics: potential for reduced renal perfusion.
  • Lithium: ibuprofen can increase lithium serum concentrations.
  • Methotrexate: may raise methotrexate levels and toxicity.

Frequently Asked Questions

Ibuprofen Dolorgiet 400 Mg Weichkapseln is an oral NSAID indicated for the relief of mild to moderate pain, reduction of fever, and management of inflammatory conditions such as osteoarthritis, rheumatoid arthritis and dysmenorrhea. It is commonly prescribed when a non‑opioid analgesic and antipyretic are required.

Ibuprofen works by non‑selectively inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2, which are key in the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels reduce inflammation, lower the hypothalamic set‑point for temperature, and decrease the sensitisation of pain receptors, providing analgesic, antipyretic and anti‑inflammatory effects.

The appropriate dose of Ibuprofen Dolorgiet 400 Mg Weichkapseln is determined by the prescribing healthcare professional based on the individual’s condition, age, weight and response to therapy. Patients should follow the prescriber’s instructions and not exceed the recommended amount.

Safety of ibuprofen during pregnancy or lactation should be evaluated by a qualified healthcare provider. Generally, ibuprofen is avoided in the third trimester of pregnancy due to potential fetal risks, and caution is advised while breastfeeding. Consultation with a physician is essential before use.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then replies with pricing, availability, shipping details and any necessary import documentation.

Ibuprofen is a non‑selective NSAID with a well‑established safety and efficacy profile. Compared with selective COX‑2 inhibitors, ibuprofen has a broader anti‑inflammatory effect but may carry a higher risk of gastrointestinal irritation. Its 400 mg soft‑gel formulation offers rapid absorption, making it comparable to other oral ibuprofen products.

Store the soft gelatin capsules at ambient temperature, preferably below 25 °C. Keep them in the original packaging to protect from moisture and direct sunlight. Do not refrigerate or freeze the capsules, as extreme temperatures may affect capsule integrity.

Ibuprofen Dolorgiet 400 Mg Weichkapseln is taken orally with a full glass of water. It may be taken with or without food, although taking it with food can reduce gastrointestinal discomfort. Swallow the soft gelatin capsule whole; do not crush or open it.

Serious risks include gastrointestinal ulceration or bleeding, renal impairment, severe hypersensitivity reactions such as anaphylaxis, and increased cardiovascular events in high‑risk patients. Patients should be monitored for signs of bleeding, changes in kidney function, or allergic reactions, and seek medical attention promptly if they occur.

Individuals with a known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulceration, severe renal or hepatic impairment, uncontrolled hypertension, or those on anticoagulant therapy without medical supervision should avoid using this product. Pregnant women in the third trimester and patients with certain cardiovascular conditions should also consult a physician before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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