Ibuprofen Flamingo Pharma Uk (Ibuprofen)

Ibuprofen acts systemically to reduce inflammation and relieve discomfort associated with several common conditions.

• Pain: provides analgesic relief by decreasing prostaglandin‑mediated sensitisation of nerve endings.
• Fever: lowers elevated body temperature through central inhibition of prostaglandin synthesis.
• Inflammation: diminishes swelling and redness in acute tissue injury.
• Arthritis: eases joint pain and stiffness by reducing inflammatory mediators in musculoskeletal disorders.

• Ibuprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin production reduces inflammation, pain signalling, and fever generation throughout the body.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

• Nausea: mild stomach upset or queasiness.
• Heartburn: burning sensation in the chest or throat.
• Headache: transient mild to moderate headache.
• Dizziness: feeling light‑headed or unsteady.
• Rash: mild skin irritation or redness.
• Diarrhoea: loose stools without blood.

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration.
• Severe allergic reaction (anaphylaxis) with swelling and difficulty breathing.
• Kidney impairment or acute renal failure.
• Liver enzyme elevation indicating hepatic stress.
• Cardiovascular events such as heart attack or stroke.
• Blood disorders like thrombocytopenia.

Before initiating ibuprofen therapy, consider the following safety measures.

• Assess renal function: avoid use in patients with severe kidney disease.
• Avoid in active peptic ulcer disease: risk of gastrointestinal bleeding is heightened.
• Use with caution in asthma: may trigger bronchospasm in sensitive individuals.
• Do not combine with other NSAIDs or aspirin: additive toxicity can occur.
• Store at ambient temperature: keep in the original pack, protect from moisture.

Ibuprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• Selective serotonin reuptake inhibitors (SSRIs): heightened gastrointestinal bleed risk.
• Lithium: ibuprofen may raise lithium serum concentrations.
• Methotrexate: reduced clearance leading to toxicity.
• ACE inhibitors: possible decline in renal function.

Moderate Interactions (Monitor Closely)

• Diuretics: may diminish renal perfusion when combined.
• Beta‑blockers: potential alteration of blood pressure control.
• Corticosteroids: additive irritation of the gastrointestinal tract.