Ibuprofen Flamingo Pharma Uk (Ibuprofen Bp)

• Ibuprofen acts as an analgesic and antipyretic by inhibiting prostaglandin synthesis, making it useful for several common conditions.
• Mild to moderate pain: provides effective analgesia for headaches, dental pain, musculoskeletal aches, and menstrual cramps.
• Fever: lowers elevated body temperature by acting on the hypothalamic heat‑regulation center, useful in infections and inflammatory fevers.
• Inflammatory conditions such as osteoarthritis and rheumatoid arthritis: reduces joint swelling, stiffness, and discomfort by decreasing local inflammation.

• Ibuprofen exerts its effect by non‑selectively inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2. This blockade reduces the conversion of arachidonic acid to prostaglandins and thromboxanes, leading to decreased synthesis of mediators that cause pain, fever, and inflammation. The inhibition of COX‑1 also affects protective gastric prostaglandins, contributing to its safety profile.

Like all NSAIDs, ibuprofen may cause a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects

• Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
• Headache: mild to moderate intensity.
• Dizziness or vertigo.
• Skin rash or mild itching.
• Elevated blood pressure (occasionally).

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulcer perforation.
• Severe allergic reactions such as anaphylaxis or angioedema.
• Acute kidney injury or worsening of chronic renal disease.
• Liver enzyme elevations or hepatitis.
• Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Before using ibuprofen, consider the following precautions to minimize risks and ensure safe therapy.

• Assess renal function: avoid or adjust dose in patients with severe renal impairment.
• Evaluate gastrointestinal risk: use with food or a proton‑pump inhibitor in those with a history of ulcers.
• Monitor bleeding risk: avoid concurrent use with anticoagulants or antiplatelet agents unless medically indicated.
• Caution in asthma: ibuprofen may precipitate bronchospasm in susceptible individuals.
• Pregnancy and lactation: consult a healthcare professional before use during pregnancy or while breastfeeding.
• Store at ambient temperature: keep in the original packaging, protect from moisture and heat.

Ibuprofen can interact with several medicines; awareness of major and moderate interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• Other NSAIDs or aspirin: additive gastrointestinal toxicity and ulcer risk.
• Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

• Corticosteroids: combined use may exacerbate gastric ulceration.
• ACE inhibitors or ARBs in volume‑depleted patients: may reduce renal perfusion and function.
• Diuretics (especially loop diuretics): can impair renal clearance of ibuprofen.
• Lithium: ibuprofen may raise lithium serum levels, increasing toxicity risk.