Product image of Ibuprofen Genrx B.V. (Ibuprofen) supplied by GNH India

Ibuprofen Genrx B.V.

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Genrx B.V. (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Genrx B.V., is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It is employed to relieve pain, reduce fever, and diminish inflammation in adults and children when appropriate.

GNH India supplies Ibuprofen Genrx B.V. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Genrx B.V.

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Indications & Clinical Uses

Ibuprofen acts systemically to control symptoms associated with inflammatory and febrile conditions.

  • Pain: provides analgesia for mild to moderate musculoskeletal, dental and postoperative discomfort.
  • Fever: lowers elevated body temperature caused by infection or inflammatory disease.
  • Inflammation: reduces swelling and stiffness in conditions such as arthritis or soft‑tissue injury.

How It Works

  • Ibuprofen reversibly inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes peripheral sensitisation of nociceptors, lowers the hypothalamic set‑point for temperature, and limits inflammatory exudate formation, producing analgesic, antipyretic, and anti‑inflammatory effects.

Side Effects

Adverse reactions may occur with ibuprofen use and are classified by frequency and severity.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia or abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash or mild pruritus.
  • Elevated blood pressure in susceptible individuals.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or perforated ulcer.
  • Acute renal impairment or failure.
  • Severe hypersensitivity reactions, including anaphylaxis.
  • Hepatotoxicity with marked liver enzyme elevation.
  • Thrombocytopenia or other hematologic abnormalities.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor for potential complications.

  • Renal function assessment: avoid or adjust dose in patients with impaired kidney function.
  • Gastrointestinal risk: use the lowest effective dose, especially in those with a history of ulcer disease.
  • Cardiovascular caution: monitor blood pressure and avoid in uncontrolled hypertension.
  • Hypersensitivity: discontinue if signs of allergic reaction appear.
  • Concomitant anticoagulants: increase vigilance for bleeding.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ibuprofen may alter the pharmacodynamics or pharmacokinetics of several medicines.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened risk of serious bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Corticosteroids: increased chance of ulceration and bleeding.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal perfusion, especially in volume‑depleted patients.
  • Diuretics: potential for reduced antihypertensive effect and renal impairment.
  • Lithium or methotrexate: ibuprofen can raise serum concentrations, requiring dose adjustment.

Frequently Asked Questions

Ibuprofen Genrx B.V. is a generic formulation of ibuprofen, an NSAID indicated for the relief of mild to moderate pain, reduction of fever, and mitigation of inflammation associated with conditions such as arthritis, dental procedures, musculoskeletal injuries, and common infections.

Ibuprofen works by reversibly blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for the synthesis of prostaglandins. By lowering prostaglandin levels, it reduces pain signalling, lowers elevated body temperature, and diminishes inflammatory swelling.

The appropriate dose of ibuprofen is individualized by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and response to therapy. Dosage regimens are not standardized in this description and should follow the prescriber’s instructions.

Ibuprofen is generally avoided during the third trimester of pregnancy because of potential fetal cardiovascular effects. Use during the first two trimesters should be limited to situations where the benefit outweighs risk, and only under medical advice. Small amounts are excreted in breast milk; nursing mothers should consult a clinician before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

The primary alternative to ibuprofen within the NSAID class is naproxen, which has a longer half‑life and may require less frequent dosing. Compared with acetaminophen, ibuprofen adds anti‑inflammatory activity but carries a higher risk of gastrointestinal and renal side effects. Choice depends on the therapeutic goal and patient‑specific risk profile.

Ibuprofen should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, excessive heat and direct sunlight to maintain stability and potency throughout its shelf life.

Ibuprofen is administered orally, typically as tablets, capsules, or liquid suspension. It should be taken with a full glass of water, and may be taken with food or milk to lessen gastrointestinal discomfort. The exact route and form depend on the specific product supplied.

Serious risks include gastrointestinal bleeding or perforation, severe allergic reactions such as anaphylaxis, acute kidney injury, and cardiovascular events like heart attack or stroke, especially with high‑dose or prolonged use. Patients should seek immediate medical attention if they notice black stools, vomiting blood, sudden swelling, or difficulty breathing.

Ibuprofen is contraindicated in individuals with known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal ulceration, severe heart failure, or uncontrolled hypertension. It should also be avoided in patients receiving certain anticoagulants without close monitoring, and in the third trimester of pregnancy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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