Product image of Ibuprofen Hexal (Ibuprofen) supplied by GNH India

Ibuprofen Hexal

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Hexal (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Hexal, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an oral tablet for systemic use. It is used to relieve mild to moderate pain, reduce fever, and diminish inflammation in conditions such as arthritis.

GNH India supplies Ibuprofen Hexal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to European Union quality standards and provides reliable distribution to health‑care providers across multiple regions.

Manufacturer / TM Owner

Hexal A/S

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Indications & Clinical Uses

Ibuprofen acts on the cyclooxygenase pathway to provide analgesic, antipyretic and anti‑inflammatory effects.

  • Pain: Reduces mild to moderate acute or chronic pain such as headache, dental pain or musculoskeletal discomfort.
  • Fever: Lowers elevated body temperature associated with infections or inflammatory conditions.
  • Inflammation: Decreases swelling and stiffness in inflammatory disorders, including osteoarthritis and rheumatoid arthritis.
  • Arthritis: Improves joint mobility and reduces pain in osteoarthritis and rheumatoid arthritis.

How It Works

  • Ibuprofen inhibits both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate pain, fever and inflammation. By reducing prostaglandin levels, it attenuates peripheral nociceptor sensitization and lowers the hypothalamic set‑point for body temperature.

Side Effects

Ibuprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash or mild itching.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Renal impairment or acute kidney injury.
  • Hepatotoxicity: elevated liver enzymes or hepatitis.
  • Severe hypersensitivity reactions: anaphylaxis or Stevens‑Johnson syndrome.

Precautions & Warnings

When using ibuprofen, several safety considerations should be observed.

  • Assess renal function: avoid use in patients with severe kidney disease.
  • Monitor gastrointestinal risk: consider gastro‑protective agents in those with ulcer history.
  • Evaluate cardiovascular status: use cautiously in individuals with hypertension or heart disease.
  • Avoid use during the third trimester of pregnancy: potential fetal complications.
  • Review concomitant medications: check for interactions with anticoagulants, antihypertensives or other NSAIDs.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • High‑dose aspirin: heightened gastrointestinal toxicity and reduced cardioprotective effect.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may diminish antihypertensive response and affect renal function.
  • Diuretics: potential for reduced diuretic efficacy and kidney injury.
  • Selective serotonin reuptake inhibitors (SSRIs): elevated risk of gastrointestinal bleeding.

Frequently Asked Questions

Ibuprofen Hexal is used to relieve mild to moderate pain, lower fever, and reduce inflammation. It is commonly prescribed for conditions such as headache, dental pain, musculoskeletal aches, and inflammatory joint disorders like osteoarthritis and rheumatoid arthritis.

Ibuprofen works by inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for the production of prostaglandins. Lower prostaglandin levels decrease the sensation of pain, lower elevated body temperature, and reduce swelling and inflammation at the site of injury.

The appropriate dose of Ibuprofen Hexal is determined by the prescribing healthcare professional based on the patient’s age, weight, medical condition, and response to therapy. Dosage may vary for acute pain, chronic conditions, or fever, and should always follow the prescriber’s instructions.

Ibuprofen should be used with caution during pregnancy, especially in the third trimester, because it may affect fetal cardiovascular development. While limited data exist for breastfeeding, small amounts can pass into breast milk. Consultation with a physician is essential before use in either situation.

To order Ibuprofen Hexal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Ibuprofen and naproxen belong to the same NSAID class and share similar mechanisms of COX inhibition. Ibuprofen generally has a shorter half‑life, requiring more frequent dosing, whereas naproxen provides longer pain relief with once‑ or twice‑daily dosing. Both have comparable efficacy, but individual tolerability and specific risk profiles may influence the choice.

Ibuprofen Hexal tablets should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, direct sunlight, and excessive heat. Ensure the container is tightly closed to maintain stability throughout its shelf life.

Ibuprofen Hexal is administered orally. The tablets are swallowed whole with a full glass of water, preferably with food or milk to minimize gastrointestinal irritation. The exact administration schedule is determined by the prescribing clinician.

Serious risks include gastrointestinal bleeding or ulceration, severe kidney injury, liver toxicity, and hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice black stools, sudden loss of kidney function, severe rash, or difficulty breathing.

Individuals with known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal ulcers, severe renal or hepatic impairment, and patients in the third trimester of pregnancy should avoid using Ibuprofen Hexal. Additionally, it is contraindicated in patients taking certain anticoagulants without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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