Ibuprofen Hexal (Ibuprofen)

Ibuprofen acts on the cyclo‑oxygenase pathway to alleviate pain, fever and inflammation.

• Mild to moderate pain: provides analgesia for everyday aches and injuries.
• Fever: lowers elevated body temperature.
• Arthritis: reduces joint inflammation and improves mobility.
• Headache: eases tension‑type and mild migraine symptoms.
• Dental pain: helps control pain after procedures.
• Dysmenorrhea: relieves menstrual cramps.

• Ibuprofen reversibly inhibits cyclo‑oxygenase enzymes COX‑1 and COX‑2, decreasing the conversion of arachidonic acid to prostaglandins. This reduction in prostaglandin synthesis diminishes inflammation, pain signaling, and fever generation at the site of tissue injury or infection.

Ibuprofen may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia, or heartburn.
• Headache or dizziness.
• Mild skin rash or itching.
• Elevated blood pressure in some patients.
• Transient increase in serum creatinine.

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding.
• Severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome.
• Hepatotoxicity or liver enzyme elevation.
• Renal impairment or acute kidney injury.
• Cardiovascular events including myocardial infarction or stroke.

Before using Ibuprofen Hexal, consider the following safety measures.

• Cardiovascular risk: avoid in patients with uncontrolled hypertension or recent heart events.
• Gastrointestinal safety: use with caution in those with a history of ulcers or bleeding.
• Renal function: monitor kidney health in patients with chronic kidney disease.
• Pregnancy and lactation: consult a healthcare professional before use.
• Concomitant medications: review all current drugs for potential interactions.
• Store at ambient temperature: keep below 25°C in the original packaging, protected from moisture and direct sunlight.

Ibuprofen can affect the activity of several other medicines.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• High‑dose aspirin: heightened gastrointestinal toxicity.
• Selective COX‑2 inhibitors: additive renal and cardiovascular effects.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in antihypertensive efficacy.
• Diuretics: potential for decreased renal perfusion.
• Lithium: risk of elevated serum lithium levels.
• Methotrexate: reduced clearance leading to toxicity.