Product image of Ibuprofen supplied by GNH India

Ibuprofen

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen

Ibuprofen, the active ingredient in Ibuprofen, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It relieves pain, reduces fever, and diminishes inflammation, including symptoms of arthritis, in adults and children as appropriate. It is available over the counter in many European markets and is commonly used for short‑term symptom management.

GNH India supplies Ibuprofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches for global distribution.

Manufacturer / TM Owner

Us Pharmacia Sp. Z O.O.

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Indications & Clinical Uses

Ibuprofen acts on inflammatory pathways to provide analgesic, antipyretic, and anti‑inflammatory effects.

  • Pain: Reduces mild to moderate pain such as headache, dental pain, or musculoskeletal discomfort.
  • Fever: Lowers elevated body temperature associated with infections or inflammatory conditions.
  • Inflammation: Decreases swelling and stiffness in conditions like osteoarthritis or rheumatoid arthritis.
  • Arthritis: Alleviates joint pain and improves mobility in osteoarthritis and rheumatoid arthritis.

How It Works

  • Ibuprofen exerts its effect by reversibly inhibiting cyclooxygenase enzymes COX‑1 and COX‑2, which are key in the conversion of arachidonic acid to prostaglandins. By reducing prostaglandin synthesis, it diminishes peripheral sensitization of nociceptors, lowers the hypothalamic set‑point for temperature, and limits inflammatory exudate formation. The inhibition is dose‑dependent and temporary, allowing normal prostaglandin production to resume after the drug is cleared.

Side Effects

Ibuprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Headache: mild to moderate headache.
  • Dizziness: transient feeling of light‑headedness.
  • Rash: mild skin erythema or itching.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding: potentially life‑threatening hemorrhage.
  • Renal impairment: acute kidney injury especially with dehydration.
  • Severe hypersensitivity: anaphylaxis or Stevens‑Johnson syndrome.

Precautions & Warnings

When using ibuprofen, consider the following precautions to minimize risk.

  • Assess renal function: avoid use in patients with severe kidney disease or dehydration.
  • Evaluate cardiovascular risk: use cautiously in individuals with hypertension, heart failure or coronary artery disease.
  • Monitor gastrointestinal health: patients with a history of ulcers or bleeding should use protective agents or alternative therapy.
  • Review concomitant medications: avoid concurrent use with other NSAIDs, anticoagulants, or corticosteroids without medical guidance.
  • Pregnancy and lactation: consult a healthcare professional before use during pregnancy or breastfeeding.
  • Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can interact with several medicines; awareness of major and moderate interactions helps ensure safe use.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • High‑dose aspirin: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.
  • Angiotensin‑converting enzyme inhibitors or ARBs: may reduce renal protective effects.
  • Lithium: ibuprofen can raise lithium serum levels.

Moderate Interactions (Monitor Closely)

  • Diuretics: possible reduction in antihypertensive efficacy.
  • Methotrexate: decreased renal clearance leading to toxicity.
  • Corticosteroids: enhanced risk of gastrointestinal ulceration.
  • Antihypertensive agents: may blunt blood pressure control.
  • Antidiabetic drugs: potential alteration of glucose control.

Frequently Asked Questions

Ibuprofen is an over‑the‑counter nonsteroidal anti‑inflammatory drug used to relieve mild to moderate pain, reduce fever, and decrease inflammation associated with conditions such as headaches, dental pain, musculoskeletal aches, and various forms of arthritis.

Ibuprofen works by reversibly inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2, which are essential for converting arachidonic acid into prostaglandins. Lower prostaglandin levels reduce pain signaling, lower the hypothalamic set‑point for temperature, and limit the inflammatory response.

The appropriate dose of ibuprofen is determined by a qualified healthcare professional based on the individual’s age, weight, medical condition, and other medications. Patients should follow the prescriber’s instructions and the product labeling for safe use.

Ibuprofen should be used during pregnancy only if clearly needed and prescribed by a healthcare provider, especially after the first trimester. It is generally discouraged during breastfeeding unless advised by a clinician, as small amounts can pass into breast milk.

To order ibuprofen, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with acetaminophen, ibuprofen provides both analgesic and anti‑inflammatory effects, whereas acetaminophen lacks significant anti‑inflammatory activity. Compared with other NSAIDs such as naproxen, ibuprofen has a shorter half‑life, allowing more flexible dosing but may require more frequent administration for sustained relief.

Ibuprofen tablets should be stored at ambient temperature, preferably below 25 °C, in the original container to protect them from moisture and direct sunlight. Keep the product out of reach of children and do not use after the expiration date.

Ibuprofen is taken orally, usually with a full glass of water. It can be taken with or without food; however, taking it with food or milk may reduce gastrointestinal discomfort. Swallow tablets whole; do not crush or chew unless the formulation specifically allows it.

Serious risks include gastrointestinal bleeding or ulceration, severe allergic reactions such as anaphylaxis, and renal impairment, especially in patients with pre‑existing kidney disease or dehydration. Any signs of black stools, sudden kidney problems, or severe skin reactions should prompt immediate medical attention.

Individuals with known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal ulcers, severe heart failure, uncontrolled hypertension, or significant renal impairment should avoid ibuprofen unless directed by a physician. It is also contraindicated in patients taking certain anticoagulants without careful monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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