Product image of Ibuprofen supplied by GNH India

Ibuprofen

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen

Ibuprofen, the active ingredient in Ibuprofen, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as a unknown/unknown for oral use. It treats pain, fever, inflammation and arthritis in adults and children as appropriate.

GNH India supplies Ibuprofen as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

  • Ibuprofen works by reducing inflammation and pain pathways, making it useful for several common conditions.
  • Pain: provides relief from mild to moderate aches and soreness.
  • Fever: lowers elevated body temperature.
  • Inflammation: decreases swelling associated with injuries or chronic conditions.
  • Arthritis: alleviates joint pain and stiffness in osteoarthritis and rheumatoid arthritis.

How It Works

  • Ibuprofen reversibly inhibits cyclooxygenase‑1 and cyclooxygenase‑2 (COX‑1 and COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin synthesis diminishes inflammation, pain signaling, and fever generation at the site of tissue injury or systemic response.

Side Effects

Adverse reactions can range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Nausea or upset stomach
  • Heartburn or dyspepsia
  • Dizziness or light‑headedness
  • Headache

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration
  • Severe allergic reaction (anaphylaxis, skin rash, swelling)
  • Elevated liver enzymes or hepatic injury
  • Kidney impairment or reduced renal function
  • Cardiovascular thrombotic events such as heart attack or stroke

Precautions & Warnings

  • Before using ibuprofen, consider the following safety measures.
  • Assess renal function: evaluate kidney health, especially in the elderly or those with chronic disease.
  • Evaluate gastrointestinal risk: avoid in patients with active ulcers or a history of serious GI bleeding.
  • Monitor cardiovascular status: use cautiously in individuals with heart disease or hypertension.
  • Avoid concurrent NSAIDs or anticoagulants: increased risk of bleeding and ulceration.
  • Store at room temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Ibuprofen can interact with several medicines; awareness helps prevent complications.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • High‑dose aspirin: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): increased chance of GI bleeding.

Moderate Interactions (Monitor Closely)

  • Diuretics: may reduce renal clearance of ibuprofen.
  • Lithium: ibuprofen can raise lithium levels, risking toxicity.
  • Methotrexate: reduced elimination may enhance methotrexate toxicity.

Frequently Asked Questions

Ibuprofen is an over‑the‑counter NSAID indicated for the relief of mild to moderate pain, reduction of fever, control of inflammation, and management of arthritis‑related joint discomfort. It is commonly used for headaches, dental pain, musculoskeletal aches, and febrile illnesses.

Ibuprofen blocks the activity of cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for producing prostaglandins. By lowering prostaglandin levels, it reduces the signals that cause pain, fever, and inflammation at the site of injury or infection.

The appropriate ibuprofen dose is determined by a prescriber or according to the product label. Dosage depends on the patient’s age, weight, indication, and formulation, and should be taken exactly as directed by a healthcare professional.

Safety of ibuprofen in pregnancy and lactation is not fully established. It is generally avoided in the third trimester and used only if the benefit outweighs the risk. Breastfeeding mothers should consult a healthcare provider before use.

To request ibuprofen, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ibuprofen and acetaminophen both relieve pain and fever, but ibuprofen also has anti‑inflammatory properties due to COX inhibition. Acetaminophen lacks significant anti‑inflammatory effects and has a different safety profile, especially regarding gastrointestinal and renal considerations.

Ibuprofen should be stored at room temperature, below 25 °C, in its original packaging. Keep it away from moisture, direct sunlight, and excessive heat to maintain product stability.

Ibuprofen is taken orally, usually as a tablet, capsule, or liquid suspension. It should be swallowed with a full glass of water, and may be taken with food or milk to lessen stomach irritation.

Serious risks include gastrointestinal bleeding or ulceration, severe allergic reactions such as anaphylaxis, kidney injury, and increased cardiovascular events like heart attack or stroke, particularly with high‑dose or prolonged use.

Individuals with a known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulcers, severe heart failure, uncontrolled hypertension, or those on certain anticoagulants should avoid ibuprofen unless advised otherwise by a clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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