Product image of Ibuprofen supplied by GNH India

Ibuprofen

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen

Ibuprofen, the active ingredient in Ibuprofen, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It treats pain, fever and inflammation in adults and children when appropriate.
GNH India supplies Ibuprofen as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Us Pharmacia Sp. Z O.O.

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Indications & Clinical Uses

  • Ibuprofen acts on inflammatory pathways to relieve a range of common conditions.
  • Pain: Provides relief from mild to moderate pain such as headache, dental pain, or musculoskeletal discomfort.
  • Fever: Reduces elevated body temperature associated with infections or inflammatory states.
  • Inflammation: Decreases swelling and redness in conditions like sprains or minor injuries.
  • Arthritis: Alleviates joint pain and stiffness in osteoarthritis and rheumatoid arthritis.

How It Works

  • Ibuprofen reversibly inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes inflammation, pain signaling, and fever generation at the site of tissue injury or infection.

Side Effects

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
  • Headache: mild to moderate tension‑type headache.
  • Dizziness or vertigo: transient sensation of light‑headedness.
  • Skin rash: mild erythema or pruritus.
  • Elevated blood pressure: modest increase in some patients.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Acute renal impairment or worsening of chronic kidney disease.
  • Severe allergic reactions including anaphylaxis.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatic injury: elevated liver enzymes or hepatitis.
  • Cardiovascular events: increased risk of thrombotic events in high‑risk individuals.

Precautions & Warnings

  • Before using ibuprofen, consider the following safety measures.
  • Assess renal function: adjust use in patients with impaired kidney function.
  • Monitor gastrointestinal health: avoid in active ulcer disease or recent GI bleeding.
  • Avoid concurrent NSAIDs: combined use raises bleeding risk.
  • Use with caution in pregnancy: limited data, especially avoid in the third trimester.
  • Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Ibuprofen may interact with several medicines; review the following categories.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened gastrointestinal bleeding potential.
  • Lithium: NSAIDs can raise lithium serum concentrations.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may reduce renal perfusion and function.
  • Diuretics: combined use can enhance nephrotoxic effects.
  • Methotrexate: NSAIDs may increase methotrexate toxicity.

Frequently Asked Questions

Ibuprofen is used to relieve mild to moderate pain, reduce fever, and decrease inflammation. It is commonly employed for headaches, dental pain, musculoskeletal aches, fever associated with infections, and inflammatory conditions such as arthritis.

Ibuprofen works by reversibly blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for producing prostaglandins. Lower prostaglandin levels lead to reduced pain signaling, less inflammation, and a lowered fever response.

The appropriate ibuprofen dose is determined by a prescriber based on the patient’s age, weight, condition being treated, and overall health status. Patients should follow the dosing instructions provided by their healthcare professional.

Safety of ibuprofen in pregnancy and lactation is not fully established. It is generally avoided in the third trimester and used only if clearly needed under medical supervision. Breastfeeding mothers should consult a healthcare provider before use.

To order ibuprofen, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ibuprofen shares the same COX‑inhibiting mechanism as other NSAIDs such as naproxen and diclofenac, but it has a relatively shorter half‑life and a well‑characterized safety profile. Choice among NSAIDs depends on factors like dosing frequency, gastrointestinal tolerance, and specific patient risk factors.

Ibuprofen tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original packaging, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Ibuprofen is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food may reduce gastrointestinal discomfort. The tablet should be swallowed whole and not chewed or crushed unless directed by a healthcare professional.

Serious risks include gastrointestinal bleeding or ulcer perforation, acute kidney injury, severe allergic reactions such as anaphylaxis, and rare skin conditions like Stevens‑Johnson syndrome. Patients with a history of these issues should discuss alternatives with their prescriber.

Individuals with active gastrointestinal ulcers, severe renal impairment, known hypersensitivity to ibuprofen or other NSAIDs, and those in the third trimester of pregnancy should avoid ibuprofen. It should also be used cautiously in patients taking anticoagulants or certain antihypertensive medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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