Ibuprofen Inn-Farm (Ibuprofen Lysine)

Ibuprofen acts on the cyclooxygenase pathway to alleviate pain, fever and inflammation.

• Pain (mild to moderate): Provides analgesic relief by lowering prostaglandin‑mediated pain signals.
• Fever: Reduces elevated body temperature through inhibition of prostaglandin synthesis in the hypothalamus.
• Inflammatory arthritis: Decreases joint swelling and stiffness associated with osteoarthritis and rheumatoid arthritis.

• Ibuprofen lysine reversibly inhibits both COX‑1 and COX‑2 enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin levels reduces inflammation, lowers fever, and diminishes pain perception at peripheral and central sites.

Adverse reactions may occur with ibuprofen use and vary in frequency.

Common Side Effects

• Gastrointestinal discomfort such as nausea or dyspepsia.
• Headache or dizziness.
• Mild skin rash or itching.
• Elevated blood pressure in susceptible individuals.

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding.
• Severe hypersensitivity reactions including anaphylaxis.
• Renal impairment or acute kidney injury.
• Hepatotoxicity manifested by abnormal liver enzymes.

Before using ibuprofen, consider the following safety measures.

• Cardiovascular risk: Use the lowest effective dose for the shortest duration, especially in patients with heart disease.
• Gastrointestinal protection: Assess history of ulcers or bleeding; consider gastro‑protective agents if needed.
• Renal function: Monitor kidney function in patients with pre‑existing renal disease or dehydration.
• Pregnancy and lactation: Discuss risks with a healthcare professional; avoid unless clearly indicated.
• Drug interactions: Review concomitant medications for potential additive NSAID effects.
• Store at ambient temperature: Keep below 25 °C, retain in original packaging, and protect from moisture.

Ibuprofen can affect the activity of several other medicines.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): Increased risk of serious bleeding.
• High‑dose aspirin: Enhanced gastrointestinal toxicity.
• Selective COX‑2 inhibitors: Additive cardiovascular risk.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: May reduce antihypertensive effect and impair renal function.
• Diuretics: Potential for decreased renal perfusion.
• Lithium: Ibuprofen can raise lithium serum concentrations.
• Methotrexate (low dose): May increase methotrexate toxicity.