Product image of Ibuprofen Kabi (Ibuprofen) supplied by GNH India

Ibuprofen Kabi

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Kabi (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Kabi, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an injection solution for intravenous use. It is employed to manage acute pain, postoperative discomfort, fever, and various inflammatory conditions in adult patients in hospital settings.

GNH India supplies Ibuprofen Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company adheres to stringent quality standards and provides reliable logistics for global healthcare providers. Our distribution network ensures timely delivery to acute care facilities across continents.

Manufacturer / TM Owner

Fresenius Kabi S.R.O.

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Indications & Clinical Uses

  • Ibuprofen Kabi, an intravenous NSAID, is used to treat conditions involving pain, fever, and inflammation.
  • Acute Pain: provides rapid analgesia for moderate to severe pain.
  • Post‑operative Pain: reduces discomfort after surgical procedures.
  • Fever: lowers elevated body temperature in febrile patients.
  • Inflammatory Conditions: alleviates inflammation such as musculoskeletal or postoperative inflammatory responses.

How It Works

  • Ibuprofen Kabi exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes peripheral sensitization of nociceptors, lowers the hypothalamic set‑point for temperature, and decreases inflammatory exudate formation, resulting in analgesic, antipyretic, and anti‑inflammatory actions. Because both COX isoforms are affected, the drug provides broad coverage of prostaglandin‑mediated pathways while maintaining a rapid onset when administered intravenously.

Side Effects

Intravenous ibuprofen may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea
  • Headache
  • Dizziness
  • Injection site pain
  • Mild gastrointestinal discomfort
  • Transient elevation of liver enzymes

Serious or Rare Side Effects

  • Anaphylactic reaction
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Gastrointestinal bleeding or ulcer perforation
  • Acute renal failure
  • Cardiovascular thrombotic events
  • Severe skin reactions such as DRESS (drug reaction with eosinophilia and systemic symptoms)

Precautions & Warnings

  • Before using Ibuprofen Kabi, clinicians should evaluate patient risk factors and monitor for potential complications.
  • Assess renal function: evaluate baseline creatinine and adjust use in renal impairment.
  • Monitor hepatic enzymes: check liver function before and during therapy.
  • Use caution in cardiovascular disease: consider risk of thrombotic events.
  • Avoid in active peptic ulcer disease: increased risk of GI bleeding.
  • Review concomitant anticoagulant therapy: heightened bleeding potential.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ibuprofen Kabi can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • ACE inhibitors or ARBs: may reduce renal perfusion.

Moderate Interactions (Monitor Closely)

  • Diuretics: potential for renal function decline.
  • SSRIs or SNRIs: modest increase in bleeding risk.

Frequently Asked Questions

Ibuprofen Kabi is an intravenous formulation of ibuprofen used in hospital settings to provide rapid relief of acute pain, postoperative discomfort, fever, and inflammation associated with various conditions such as musculoskeletal injuries or surgical procedures.

Ibuprofen inhibits both COX‑1 and COX‑2 enzymes, reducing the synthesis of prostaglandins that mediate pain, fever, and inflammation. By lowering prostaglandin levels, it diminishes peripheral sensitization of pain receptors, resets the hypothalamic temperature set‑point, and limits inflammatory exudate formation.

The dosage of Ibuprofen Kabi is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and response to therapy. Healthcare professionals set the appropriate infusion rate and total daily amount according to established hospital protocols.

Safety data for intravenous ibuprofen in pregnancy and lactation are limited. The product should be used only if the potential benefit justifies the potential risk to the fetus or infant, and decisions should be made by the treating physician in consultation with obstetric specialists.

To request Ibuprofen Kabi, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Compared with other IV NSAIDs, ibuprofen offers a well‑characterized safety profile and effective analgesia at lower cardiovascular risk than selective COX‑2 inhibitors. Unlike opioids, it does not cause respiratory depression, but it shares typical NSAID cautions such as renal and gastrointestinal considerations.

Ibuprofen Kabi must be stored at 2‑8 °C in a refrigerator. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution. Inspect the product before use and discard any vial that appears cloudy or contains particles.

The medication is supplied as a sterile injection solution for intravenous infusion. It is administered by a healthcare professional through a dedicated IV line, typically diluted in compatible IV fluids and infused over a short period as directed by the prescribing protocol.

Serious risks include severe allergic reactions such as anaphylaxis, gastrointestinal bleeding or ulcer perforation, acute kidney injury, and cardiovascular events like myocardial infarction or stroke. Prompt recognition and management of these events are essential, and patients should be monitored closely during therapy.

Ibuprofen Kabi should be avoided in patients with known hypersensitivity to ibuprofen or other NSAIDs, active peptic ulcer disease, severe uncontrolled heart failure, significant renal impairment, and in those receiving anticoagulant therapy where bleeding risk is high, unless the prescriber determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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