Product image of Ibuprofen Kabi (Ibuprofen) supplied by GNH India

Ibuprofen Kabi

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Kabi (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Kabi, is a nonsteroidal anti-inflammatory drug presented as an intravenous solution for intravenous use. It treats mild to moderate pain, fever and inflammation, including post‑operative pain, in adult patients.

GNH India supplies Ibuprofen Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Fresenius Kabi Hungary Kft.

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Indications & Clinical Uses

  • Ibuprofen Kabi, an intravenous NSAID, is employed in clinical settings to manage pain, fever and inflammation.
  • Mild to moderate pain: provides rapid analgesia for acute surgical or injury‑related discomfort.
  • Fever: lowers elevated body temperature in peri‑operative patients.
  • Inflammation: reduces postoperative or traumatic inflammatory response.

How It Works

  • Ibuprofen Kabi exerts its effect by reversibly inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, blocking the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis diminishes peripheral nociceptor sensitisation, lowers the hypothalamic temperature set‑point, and curtails inflammatory mediators, producing analgesic, antipyretic and anti‑inflammatory actions.

Side Effects

Intravenous ibuprofen may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Dizziness: light‑headed sensation.
  • Injection site pain: local discomfort at the IV site.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate treatment.
  • Renal impairment: acute kidney injury, especially in volume‑depleted patients.
  • Gastrointestinal bleeding: ulceration or hemorrhage.

Precautions & Warnings

  • When using Ibuprofen Kabi, clinicians should observe several safety considerations.
  • Renal function: assess baseline kidney function and avoid in severe renal impairment.
  • Bleeding risk: use cautiously in patients with coagulopathy or on anticoagulants.
  • Cardiovascular status: monitor in patients with hypertension or heart failure.
  • Gastrointestinal history: avoid in active ulcer disease.
  • Pregnancy and lactation: use only if benefits outweigh risks, as safety data are limited.
  • Store at 2‑8 °C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ibuprofen Kabi can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: additive toxicity.
  • High‑dose aspirin: enhanced gastrointestinal adverse effects.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal perfusion.
  • Diuretics: risk of renal dysfunction.
  • Lithium: ibuprofen may increase lithium serum levels.

Frequently Asked Questions

Ibuprofen Kabi is an intravenous formulation of ibuprofen used in hospitals to provide rapid relief of mild to moderate pain, to reduce fever, and to control inflammation, especially after surgery or trauma. It is administered under medical supervision and is indicated for adult patients requiring parenteral therapy.

Ibuprofen works by reversibly inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for converting arachidonic acid into prostaglandins. By lowering prostaglandin levels, it reduces pain signalling, lowers the hypothalamic set‑point for temperature, and diminishes the inflammatory response.

The dosing regimen for Ibuprofen Kabi is determined by the prescribing clinician based on the patient’s condition, weight, renal function and other clinical factors. The prescriber selects the appropriate dose, infusion rate and treatment duration according to current medical guidelines.

Safety data for intravenous ibuprofen in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified health professional.

To order Ibuprofen Kabi, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and any required import documentation.

Ibuprofen Kabi offers a familiar NSAID profile with reversible COX inhibition, similar to other IV agents such as ketorolac. Compared with ketorolac, ibuprofen generally has a lower risk of renal toxicity at equivalent analgesic doses, but both share gastrointestinal and bleeding risks. Choice depends on the clinical scenario, patient tolerance and institutional protocols.

Ibuprofen Kabi must be stored refrigerated at 2 °C to 8 °C. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the solution. If the product is inadvertently exposed to temperatures outside this range, it should be discarded.

Ibuprofen Kabi is given by intravenous infusion. The solution is diluted in an appropriate compatible fluid and administered over a short period, typically 15–30 minutes, under continuous monitoring of vital signs and infusion site. Administration is performed by qualified healthcare personnel in a clinical setting.

The most serious risks include severe allergic reactions such as anaphylaxis, acute renal impairment especially in patients with pre‑existing kidney disease or volume depletion, and gastrointestinal bleeding or ulceration. Prompt recognition and management of these events are essential.

Ibuprofen Kabi should be avoided in patients with known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal bleeding or ulcer disease, severe renal insufficiency, uncontrolled hypertension, and in individuals for whom the risk of bleeding outweighs the therapeutic benefit.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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