Product image of Ibuprofen Kabi (Ibuprofen) supplied by GNH India

Ibuprofen Kabi

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Kabi (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Kabi, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an intravenous solution for intravenous use. It provides analgesic, antipyretic and anti‑inflammatory effects for mild to moderate pain, fever and postoperative or musculoskeletal inflammation in adult patients.

GNH India supplies Ibuprofen Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi Polska Sp. Z O.O.

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Indications & Clinical Uses

  • Ibuprofen Kabi is an NSAID indicated for conditions involving pain, fever and inflammation.
  • Mild to moderate pain: Provides rapid analgesic relief for acute or chronic pain states.
  • Fever: Reduces elevated body temperature through central antipyretic action.
  • Inflammation: Decreases swelling and tissue irritation in inflammatory disorders.
  • Post‑operative pain: Controls postoperative discomfort after surgical procedures.
  • Musculoskeletal pain: Alleviates pain associated with strains, sprains and arthritis.

How It Works

  • Ibuprofen Kabi exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting reduction in prostaglandin synthesis diminishes peripheral sensitisation, lowers the hypothalamic set‑point for temperature, and limits inflammatory exudate formation, producing analgesic, antipyretic and anti‑inflammatory outcomes.

Side Effects

Adverse reactions may occur with any intravenous NSAID. The following lists observed events.

Common Side Effects

  • Nausea or vomiting
  • Dyspepsia or abdominal discomfort
  • Headache
  • Dizziness or light‑headedness
  • Injection‑site pain or erythema
  • Transient rise in blood pressure

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration
  • Acute renal impairment or failure
  • Severe hypersensitivity reactions, including anaphylaxis
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Hepatic dysfunction or elevated transaminases
  • Thrombocytopenia or coagulation abnormalities

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety measures.
  • Assess renal function: Adjust use in patients with impaired kidney function.
  • Monitor hepatic enzymes: Watch for signs of liver injury during prolonged therapy.
  • Use lowest effective dose: Minimise exposure while achieving therapeutic goals.
  • Avoid in known hypersensitivity: Do not administer to patients with previous ibuprofen or NSAID allergy.
  • Caution in cardiovascular disease: NSAIDs may increase risk of thrombotic events.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ibuprofen Kabi can interact with several drug classes, requiring vigilance.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): Heightened bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: Additive gastrointestinal toxicity.
  • Corticosteroids: Increased risk of ulceration and bleeding.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: Potential for reduced renal perfusion.
  • Diuretics: May exacerbate renal function decline.
  • Methotrexate: Decreased clearance leading to toxicity.

Frequently Asked Questions

Ibuprofen Kabi is an intravenous formulation of ibuprofen used to treat mild to moderate pain, reduce fever, and control inflammation. It is commonly employed in postoperative settings, musculoskeletal injuries, and other conditions where rapid analgesic and antipyretic effects are needed.

Ibuprofen works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for converting arachidonic acid into prostaglandins. By lowering prostaglandin levels, it reduces pain signaling, lowers fever, and diminishes inflammatory swelling.

The specific dose and infusion rate of Ibuprofen Kabi are determined by the prescribing clinician based on the patient’s condition, weight, renal function and other clinical factors. Healthcare professionals should follow local guidelines and product labeling when prescribing.

Safety data for intravenous ibuprofen in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To request Ibuprofen Kabi, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Compared with other IV NSAIDs, ibuprofen offers a well‑characterised safety profile and effective analgesia at lower gastrointestinal risk than some COX‑2 selective agents. Unlike opioids, it does not cause respiratory depression, but it shares class‑related risks such as renal impairment and bleeding, which must be weighed against therapeutic benefits.

Ibuprofen Kabi must be stored refrigerated between 2 °C and 8 °C. Keep the vials in their original packaging, protect them from light, and do not freeze or agitate the solution. If the product reaches room temperature, it should be used promptly and not re‑refrigerated.

Ibuprofen Kabi is given by intravenous infusion. The medication is diluted according to the manufacturer’s instructions and administered over a short period, typically 15–30 minutes, under the supervision of qualified healthcare personnel in a clinical setting.

Serious risks include gastrointestinal bleeding or ulceration, acute kidney injury, severe allergic reactions such as anaphylaxis, and rare but life‑threatening skin reactions like Stevens‑Johnson syndrome. Patients should be monitored for signs of bleeding, renal dysfunction, or hypersensitivity during treatment.

Ibuprofen Kabi is contraindicated in patients with known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal bleeding, severe renal or hepatic impairment, and in those who have experienced a previous severe reaction to any COX‑inhibiting drug. Caution is also advised for patients with uncontrolled hypertension or cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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