Product image of Ibuprofen Kabi (Ibuprofen) supplied by GNH India

Ibuprofen Kabi

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Kabi (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Kabi, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an intravenous solution for intravenous use. It treats mild to moderate pain, fever, inflammation, and post‑operative pain in adult patients.\n\nGNH India supplies Ibuprofen Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Fresenius Kabi Deutschland Gmbh

1
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Indications & Clinical Uses

  • Ibuprofen Kabi belongs to the NSAID class and acts on inflammatory pathways to relieve symptoms.\n\nMild to moderate pain: provides analgesia for surgical and non‑surgical pain.\nFever: reduces elevated body temperature.\nInflammation: decreases swelling associated with musculoskeletal conditions.\nPost‑operative pain: controls pain after surgery.

How It Works

  • Ibuprofen Kabi exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which reduces the synthesis of prostaglandins responsible for pain, fever, and inflammation. This inhibition diminishes peripheral sensitisation and lowers the febrile response, providing analgesic, antipyretic, and anti‑inflammatory actions.

Side Effects

  • Adverse reactions may occur with any NSAID therapy.\n\nCommon Side Effects:\n- Nausea or dyspepsia\n- Headache or dizziness\n- Injection‑site discomfort\n- Transient elevation of liver enzymes\n- Mild renal function changes\n\nSerious or Rare Side Effects:\n- Gastrointestinal bleeding or ulceration\n- Acute renal failure or worsening chronic kidney disease\n- Severe hypersensitivity reactions including anaphylaxis\n- Stevens‑Johnson syndrome or toxic epidermal necrolysis\n- Cardiovascular thrombotic events such as myocardial infarction or stroke

Precautions & Warnings

  • Use of Ibuprofen Kabi requires careful assessment of patient risk factors.\n\nAssess renal function: avoid in severe renal impairment.\nMonitor for gastrointestinal bleeding: use with caution in patients with ulcer disease.\nUse caution in cardiovascular disease: consider increased thrombotic risk.\nAvoid in known hypersensitivity to ibuprofen or other NSAIDs.\nPregnancy and lactation: consult obstetrician, limited safety data.\nStore at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

  • Ibuprofen Kabi can interact with several drug classes, requiring clinical vigilance.\n\nMajor Interactions (Avoid):\n- Anticoagulants (e.g., warfarin): increased risk of bleeding.\n- Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.\n- ACE inhibitors in volume‑depleted patients: heightened risk of renal failure.\n\nModerate Interactions (Monitor Closely):\n- Diuretics: possible alterations in renal function.\n- Methotrexate: reduced clearance leading to toxicity.

Frequently Asked Questions

Ibuprofen Kabi is an intravenous formulation of ibuprofen used in hospital settings to provide analgesic, antipyretic, and anti‑inflammatory effects. It is indicated for mild to moderate pain, fever, inflammation, and for managing post‑operative discomfort in adult patients.

Ibuprofen works by non‑selectively inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2. This inhibition reduces the production of prostaglandins, which are mediators of pain, fever, and inflammation, thereby providing relief from these symptoms.

The dose of Ibuprofen Kabi is determined by the prescribing clinician based on the patient’s condition, weight, renal function, and overall clinical assessment. No fixed regimen is provided here; the prescriber sets the appropriate dosage and infusion rate.

Safety data for intravenous ibuprofen in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk, and a healthcare professional should be consulted before administration to pregnant or nursing individuals.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Compared with oral ibuprofen, the intravenous form offers rapid onset and predictable plasma levels, useful in patients unable to take oral medication. Relative to ketorolac, another injectable NSAID, ibuprofen has a slightly longer half‑life and a broader safety margin for gastrointestinal irritation, though both share similar renal and cardiovascular cautions.

Ibuprofen Kabi must be stored refrigerated at 2‑8 °C. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the solution. If the product reaches room temperature, it should be used promptly and not re‑refrigerated.

The medication is given by intravenous infusion. The healthcare professional selects an appropriate infusion set, dilutes the solution if required, and administers it over the prescribed time period, typically ranging from a few minutes to an hour, under aseptic conditions.

Serious risks include gastrointestinal bleeding or ulceration, acute renal failure, severe hypersensitivity reactions such as anaphylaxis, and cardiovascular events like myocardial infarction or stroke. Patients should be monitored closely for signs of bleeding, renal dysfunction, or allergic reactions during therapy.

Ibuprofen Kabi is contraindicated in patients with known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal bleeding or ulcer disease, severe renal impairment, and in the third trimester of pregnancy. Caution is also advised for individuals with uncontrolled hypertension or significant cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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