Product image of Ibuprofen Leidapharm (Ibuprofen) supplied by GNH India

Ibuprofen Leidapharm

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Leidapharm (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Leidapharm, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It treats mild to moderate pain, reduces fever, and alleviates inflammatory conditions such as arthritis in adults and children when appropriate.

GNH India supplies Ibuprofen Leidapharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Leidapharm B.V.

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Indications & Clinical Uses

Ibuprofen acts systemically to relieve pain, lower fever, and diminish inflammation across several common conditions.

  • Mild to moderate pain: provides analgesia for headaches, dental pain, musculoskeletal aches, and postoperative discomfort.
  • Fever: reduces elevated body temperature associated with infections or inflammatory states.
  • Arthritis and other inflammatory disorders: decreases joint swelling and improves mobility in osteoarthritis and rheumatoid arthritis.

How It Works

  • Ibuprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting reduction in prostaglandin synthesis diminishes peripheral sensitization of nociceptors, lowers the hypothalamic set‑point for temperature, and curtails inflammation at the site of tissue injury.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Gastrointestinal discomfort: dyspepsia, nausea, or abdominal pain.
  • Headache or dizziness.
  • Mild skin rash or itching.
  • Elevated blood pressure in some patients.
  • Transient increase in liver enzymes.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding, potentially life‑threatening.
  • Acute renal impairment or failure, especially with dehydration.
  • Severe hypersensitivity reactions, including anaphylaxis or Stevens‑Johnson syndrome.
  • Hepatotoxicity with marked liver enzyme elevation.
  • Cardiovascular events such as myocardial infarction or stroke, particularly with high‑dose or prolonged use.
  • Blood dyscrasias like thrombocytopenia or leukopenia.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Assess gastrointestinal risk: avoid in patients with active ulcers or a history of bleeding.
  • Evaluate renal function: use caution in those with chronic kidney disease or dehydration.
  • Monitor cardiovascular status: limit use in patients with established heart disease.
  • Use the lowest effective dose for the shortest duration needed.
  • Avoid use in the third trimester of pregnancy unless specifically directed by a physician.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can alter the activity of several other medicines.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Corticosteroids: heightened ulcer risk.
  • Lithium: elevated serum lithium levels.
  • ACE inhibitors or ARBs: possible reduction in renal function.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: may blunt blood‑pressure‑lowering effect.
  • Diuretics: risk of reduced renal perfusion.
  • Methotrexate: decreased clearance leading to toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): increased bleeding tendency.
  • Oral hypoglycemics: potential alteration of glucose control.

Frequently Asked Questions

Ibuprofen Leidapharm is indicated for the relief of mild to moderate pain such as headaches, dental discomfort, and musculoskeletal aches; for the reduction of fever associated with infections or inflammatory conditions; and for the management of inflammatory disorders like osteoarthritis and rheumatoid arthritis.

Ibuprofen works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the synthesis of prostaglandins. Lower prostaglandin levels diminish pain signaling, lower the hypothalamic set‑point for temperature, and limit inflammation at the site of tissue injury.

The specific dose and dosing interval are determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and response to therapy. Typical adult regimens range from 200 mg to 800 mg per dose, but the exact prescription should be individualized.

Ibuprofen should be used with caution during pregnancy. It is generally avoided in the third trimester because of potential fetal cardiovascular effects. During the first and second trimesters, it may be used if the benefit outweighs the risk. Breastfeeding mothers should consult a healthcare professional, as small amounts can pass into milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Ibuprofen shares a similar mechanism with other non‑selective NSAIDs, providing comparable analgesic and antipyretic effects. Compared with agents like naproxen, ibuprofen has a shorter half‑life, which may allow more flexible dosing but may also require more frequent administration. Its gastrointestinal risk profile is typical for non‑selective NSAIDs, and it does not possess the COX‑2 selectivity of celecoxib.

Store the tablets at room temperature, preferably below 25 °C. Keep them in the original packaging to protect from moisture and light, and ensure the container is tightly closed. Do not store in a bathroom or near a heat source.

Ibuprofen Leidapharm is taken orally with a full glass of water. It may be taken with or without food; however, taking it with food or milk can help reduce gastrointestinal discomfort. Swallow the tablet whole; do not crush or chew unless specifically instructed by a healthcare provider.

The most serious risks include gastrointestinal ulceration or bleeding, acute kidney injury, cardiovascular events such as heart attack or stroke, and severe allergic reactions like anaphylaxis or Stevens‑Johnson syndrome. Patients should be monitored for signs of these conditions, especially when using high doses or prolonged therapy.

Ibuprofen is contraindicated in individuals with known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulcer or bleeding, severe renal or hepatic impairment, and in the third trimester of pregnancy. It should also be avoided in children under the age specified for the particular formulation unless directed by a pediatrician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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