Ibuprofen Liquid Caps Suikervrij Linn (Ibuprofen)

Ibuprofen acts as an analgesic, antipyretic and anti‑inflammatory agent by inhibiting prostaglandin synthesis in the cyclooxygenase pathway.

• Pain: provides effective relief of mild to moderate nociceptive pain such as headache, dental or musculoskeletal discomfort.
• Fever: lowers elevated body temperature by acting on the hypothalamic heat‑regulation center.
• Inflammation: reduces swelling and stiffness associated with inflammatory conditions like arthritis or soft‑tissue injury.

• Ibuprofen inhibits both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins and thromboxanes. This reduction in prostaglandin synthesis diminishes peripheral sensitisation of nociceptors, lowers the hypothalamic set‑point for temperature, and limits inflammatory mediators that cause edema and pain.

Adverse reactions may occur with ibuprofen use and are categorised by frequency and severity.

Common Side Effects

• Dyspepsia: mild stomach discomfort or indigestion.
• Nausea: feeling of queasiness.
• Headache: transient mild headache.
• Dizziness: occasional light‑headed sensation.
• Rash: mild skin irritation.
• Diarrhoea: loose stools.

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding: severe stomach or intestinal lesions.
• Renal impairment: reduced kidney function or acute kidney injury.
• Hepatic injury: elevated liver enzymes or hepatitis.
• Anaphylaxis: rare severe allergic reaction with airway compromise.

Before using ibuprofen, consider the following safety measures.

• Cardiovascular risk: avoid in patients with uncontrolled hypertension or recent myocardial infarction.
• Gastrointestinal history: use cautiously in individuals with prior ulcers or bleeding disorders.
• Renal function: monitor kidney function in patients with chronic kidney disease.
• Pregnancy and lactation: consult a healthcare professional before use during pregnancy or breastfeeding.
• Drug interactions: review concomitant medications for potential interactions.
• Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Ibuprofen may interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• High‑dose aspirin: heightened gastrointestinal toxicity.
• Selective serotonin reuptake inhibitors (SSRIs): elevated bleeding risk.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function.
• Diuretics: may impair renal clearance of ibuprofen.
• Lithium: increased lithium serum levels.
• Methotrexate: reduced renal elimination leading to toxicity.