Product image of Ibuprofen Orifarm (Ibuprofen) supplied by GNH India

Ibuprofen Orifarm

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Orifarm (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Orifarm, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It provides analgesic, antipyretic and anti‑inflammatory effects for the relief of mild to moderate pain, fever and inflammatory conditions in adults.

GNH India supplies Ibuprofen Orifarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution across multiple regulatory regions, ensuring timely delivery.

Manufacturer / TM Owner

Orifarm Generics A/S

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Indications & Clinical Uses

Ibuprofen acts on inflammatory pathways to reduce pain, fever and swelling.

  • Mild to moderate pain: alleviates discomfort from headaches, dental pain, musculoskeletal aches.
  • Fever: lowers elevated body temperature associated with infections or inflammatory states.
  • Osteoarthritis: reduces joint pain and improves mobility in degenerative joint disease.
  • Rheumatoid arthritis: diminishes inflammation and pain in autoimmune joint inflammation.

How It Works

  • Ibuprofen reversibly inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis leads to diminished inflammation, lowered pain signaling, and antipyretic effects by acting on peripheral tissues and the hypothalamic thermoregulatory center.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia or abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash or mild itching.
  • Elevated blood pressure in some patients.
  • Mild renal function changes.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Acute renal failure or significant kidney impairment.
  • Cardiovascular thrombotic events such as myocardial infarction or stroke.
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome).
  • Hepatic injury with elevated liver enzymes.
  • Anaphylaxis or life‑threatening allergic reactions.

Precautions & Warnings

Use ibuprofen with caution and follow clinical guidance.

  • Assess renal function: monitor kidney parameters in patients with existing renal disease.
  • Evaluate cardiovascular risk: limit use in individuals with known heart disease or thrombotic risk.
  • Avoid in active peptic ulcer disease: consider alternative analgesics.
  • Use the lowest effective dose: limit duration to the shortest period necessary.
  • Monitor for hypersensitivity: discontinue if rash, swelling or breathing difficulty occurs.
  • Store at ambient temperature: keep in the original container, protect from moisture.

Avoid Interactions

Ibuprofen can interact with several medicines; review patient medication lists.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Corticosteroids: heightened risk of ulceration and bleeding.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal function.
  • Diuretics: potential for decreased effectiveness and renal effects.
  • SSRIs: modest increase in bleeding risk.

Frequently Asked Questions

Ibuprofen Orifarm is used to relieve mild to moderate pain, reduce fever, and treat inflammation associated with conditions such as osteoarthritis and rheumatoid arthritis. It provides analgesic, antipyretic and anti‑inflammatory effects when prescribed by a qualified healthcare professional.

Ibuprofen works by reversibly inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for prostaglandin production. Lower prostaglandin levels result in decreased inflammation, reduced pain signaling, and a lowered fever response.

The appropriate dose of Ibuprofen Orifarm is determined by the prescribing clinician based on the patient’s condition, age, weight and overall health. Patients should follow the prescriber’s instructions and never adjust the dose on their own.

Safety data for ibuprofen during pregnancy and lactation are limited. It should only be used if the potential benefit outweighs the risk, and under the guidance of a healthcare professional. Women who are pregnant, especially in the third trimester, or who are breastfeeding should discuss alternatives with their doctor.

To order Ibuprofen Orifarm, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ibuprofen shares the same class mechanism as other NSAIDs such as naproxen or diclofenac, offering comparable analgesic and anti‑inflammatory effects. Differences may include duration of action, dosing frequency, and individual tolerability. The choice of NSAID often depends on patient-specific factors and physician preference.

Ibuprofen Orifarm should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date indicated on the label.

Ibuprofen Orifarm is taken orally, usually with a full glass of water. It can be taken with or without food; however, taking it with food or milk may reduce gastrointestinal discomfort. Follow the prescriber’s directions regarding timing and frequency.

Serious risks include gastrointestinal bleeding or ulceration, acute kidney injury, and cardiovascular events such as heart attack or stroke, especially with high‑dose or prolonged use. Patients should be monitored for signs of these conditions and seek medical attention if they occur.

Ibuprofen Orifarm should be avoided in individuals with known hypersensitivity to ibuprofen or other NSAIDs, active peptic ulcer disease, severe heart failure, uncontrolled hypertension, and in the third trimester of pregnancy. Consultation with a healthcare professional is essential before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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