Product image of Ibuprofen Ovaal Kruidvat (Ibuprofen) supplied by GNH India

Ibuprofen Ovaal Kruidvat

Active Ingredient:
Ibuprofen
Origin:
EU

Ibuprofen Ovaal Kruidvat (Ibuprofen)

Ibuprofen, the active ingredient in Ibuprofen Ovaal Kruidvat, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for self‑medication in adults and children over 12 years. It is used to relieve pain, reduce fever, and diminish inflammation associated with conditions such as headache, musculoskeletal aches, and arthritis.

GNH India supplies Ibuprofen Ovaal Kruidvat as a licensed, GDP‑compliant international pharmaceutical supplier serving pharmacies, hospitals, and clinics worldwide, adhering to EU quality standards and providing reliable logistics.

Manufacturer / TM Owner

Mae Holding Bv

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Indications & Clinical Uses

  • Ibuprofen works systemically by inhibiting cyclo‑oxygenase enzymes, thereby reducing prostaglandin production and providing relief in several common painful or inflammatory conditions.
  • Pain: Provides symptomatic relief of mild to moderate pain such as headache, dental pain, or musculoskeletal discomfort.
  • Fever: Lowers elevated body temperature associated with viral or bacterial infections, helping to improve comfort.
  • Inflammation: Reduces swelling, redness, and heat in soft tissues caused by injury or inflammatory disease.
  • Arthritis: Alleviates joint pain and stiffness in osteoarthritis and rheumatoid arthritis, improving mobility.

How It Works

  • Ibuprofen inhibits both cyclo‑oxygenase‑1 (COX‑1) and cyclo‑oxygenase‑2 (COX‑2) enzymes, blocking the conversion of arachidonic acid to prostaglandins. This reduction in prostaglandin synthesis decreases inflammation, lowers fever, and diminishes the perception of pain at peripheral nerve endings and central pain pathways.

Side Effects

Ibuprofen may cause a range of adverse reactions, varying from mild and transient to serious and potentially life‑threatening.

Common Side Effects

  • Gastrointestinal discomfort (nausea, dyspepsia)
  • Headache
  • Dizziness
  • Mild rash
  • Nausea or upset stomach
  • Diarrhea

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding
  • Severe allergic reactions (anaphylaxis, angioedema)
  • Renal impairment or failure
  • Hepatotoxicity
  • Severe skin reactions (Stevens‑Johnson syndrome)

Precautions & Warnings

  • When using ibuprofen, several precautions should be observed to minimize risk and ensure safe use.
  • Assess renal function: Evaluate kidney health before initiating therapy in patients with pre‑existing renal disease.
  • Monitor cardiovascular risk: Use the lowest effective dose for the shortest duration in individuals with hypertension or heart disease.
  • Avoid use in active peptic ulcer disease: Contraindicated in patients with current gastrointestinal bleeding or ulceration.
  • Limit use during late pregnancy: Discuss with a healthcare professional before use in the third trimester.
  • Store at ambient temperature: Keep below 25 °C in the original container, protected from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can interact with other medicines, altering their effectiveness or increasing the risk of adverse events.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): Increased risk of serious bleeding.
  • Lithium: Elevated lithium serum concentrations, risk of toxicity.
  • Methotrexate: Reduced clearance leading to toxicity.
  • ACE inhibitors/ARBs: Potential for reduced renal function and hyperkalemia.

Moderate Interactions (Monitor Closely)

  • SSRIs or SNRIs: Heightened bleeding tendency.
  • Diuretics: May diminish diuretic efficacy and affect kidney function.
  • Corticosteroids: Increased risk of gastrointestinal ulceration.
  • Blood pressure medications: Possible attenuation of antihypertensive effect.

Frequently Asked Questions

Ibuprofen Ovaal Kruidvat is an over‑the‑counter NSAID indicated for the temporary relief of mild to moderate pain, reduction of fever, and mitigation of inflammation. It is commonly used for headaches, dental pain, muscle aches, joint discomfort associated with arthritis, and fever caused by viral or bacterial infections.

Ibuprofen works by blocking the cyclo‑oxygenase enzymes COX‑1 and COX‑2, which are essential for the production of prostaglandins. By reducing prostaglandin synthesis, it lessens inflammation, lowers body temperature, and diminishes the sensation of pain at both peripheral and central sites.

The appropriate dose of ibuprofen is determined by a qualified prescriber based on the individual’s age, weight, medical condition, and response to therapy. Typical adult dosing ranges are described in product labeling, but the exact regimen should always follow the healthcare professional’s recommendation.

Ibuprofen is generally avoided in the third trimester of pregnancy because it may affect fetal cardiovascular function. During the first and second trimesters, it should only be used if clearly needed and prescribed. While limited data suggest low transfer into breast milk, mothers should consult a healthcare provider before using ibuprofen while nursing.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with acetaminophen (paracetamol), ibuprofen provides both analgesic and anti‑inflammatory effects, making it more suitable for conditions involving swelling. However, ibuprofen carries a higher risk of gastrointestinal and renal side effects, whereas acetaminophen is generally gentler on the stomach but lacks anti‑inflammatory activity.

Store the tablets at ambient temperature, preferably below 25 °C, in the original packaging to protect them from moisture and direct sunlight. Keep the container tightly closed and out of reach of children. Do not use the product after the expiration date printed on the label.

Ibuprofen Ovaal Kruidvat is taken orally with a full glass of water. It can be taken with or without food; taking it with food or milk may reduce stomach irritation. Swallow the tablet whole; do not crush, chew, or split unless the product label specifically permits it.

Serious risks include gastrointestinal bleeding or ulceration, severe allergic reactions such as anaphylaxis, kidney injury, liver toxicity, and increased cardiovascular events like heart attack or stroke, especially with high‑dose or prolonged use. Seek immediate medical attention if you notice black stools, vomiting blood, severe rash, or sudden swelling.

Ibuprofen should be avoided by individuals with known hypersensitivity to ibuprofen or other NSAIDs, active peptic ulcer disease, severe heart failure, uncontrolled hypertension, significant renal or hepatic impairment, and by those in the third trimester of pregnancy unless advised otherwise by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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