Product image of Ibuprofen/Paracetamol Alkaloid-Int (Ibuprofen, Paracetamol) supplied by GNH India

Ibuprofen/Paracetamol Alkaloid-Int

Active Ingredient:
Ibuprofen, Paracetamol
Origin:
EU

Ibuprofen/Paracetamol Alkaloid-Int (Ibuprofen, Paracetamol)

Ibuprofen, the active ingredient in Ibuprofen/Paracetamol Alkaloid-Int, is a NSAID/Analgesic presented as an oral combination tablet for oral use. It treats mild to moderate pain, fever and inflammation in adults and children when appropriate. The formulation is designed for rapid absorption, offering effective relief while maintaining a favorable safety profile when used as directed. It is commonly used in postoperative care, dental procedures, and febrile illnesses.

GNH India supplies Ibuprofen/Paracetamol Alkaloid-Int as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Alkaloid-Int D.O.O.

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Indications & Clinical Uses

Ibuprofen/Paracetamol works on inflammatory pathways and pain signaling to provide relief in several common conditions.

  • Mild to moderate pain: reduces pain intensity in headaches, musculoskeletal discomfort, dental pain, and postoperative pain.
  • Fever: lowers elevated body temperature associated with infections or inflammatory conditions.
  • Inflammation: diminishes swelling and redness in conditions such as arthritis or soft‑tissue injuries.

How It Works

  • Ibuprofen inhibits cyclo‑oxygenase‑1 and cyclo‑oxygenase‑2 enzymes, decreasing prostaglandin synthesis and thereby reducing inflammation, pain and fever. Paracetamol acts centrally by inhibiting a variant of cyclo‑oxygenase in the brain and modulating serotonergic pathways, contributing to antipyretic and analgesic effects. The combined action provides additive pain relief and temperature control without significantly increasing gastric toxicity, allowing lower individual doses while achieving effective symptom control.

Side Effects

Like all medicines, the ibuprofen/paracetamol combination may cause adverse reactions, which are classified by frequency and severity.

Common Side Effects

  • Nausea: mild stomach upset.
  • Dyspepsia: indigestion or heartburn.
  • Headache: transient headache episodes.
  • Dizziness: occasional light‑headedness.

Serious or Rare Side Effects

  • Gastrointestinal bleeding: black stools or vomiting blood.
  • Severe skin reactions: rash, blistering, or Stevens‑Johnson syndrome.
  • Liver injury: jaundice, dark urine, or elevated liver enzymes.

Precautions & Warnings

Before using ibuprofen/paracetamol, consider the following precautions to ensure safe use.

  • Assess renal function: avoid use in severe kidney impairment without medical advice.
  • Evaluate hepatic health: monitor liver enzymes in patients with liver disease.
  • Limit alcohol intake: concurrent alcohol may increase risk of stomach bleeding.
  • Use lowest effective dose: to minimize gastrointestinal and cardiovascular risks.
  • Avoid use in children under recommended age: follow pediatric dosing guidelines.
  • Store at ambient temperature: keep below 25 °C in original container, protect from moisture.

Avoid Interactions

Ibuprofen/paracetamol may interact with other medicines, altering their effectiveness or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs: heightened gastrointestinal toxicity.
  • High‑dose paracetamol: risk of liver failure.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal function.
  • Diuretics: possible decrease in kidney clearance.
  • Lithium: ibuprofen can raise lithium levels.
  • Methotrexate: ibuprofen may increase toxicity.

Frequently Asked Questions

Ibuprofen/Paracetamol Alkaloid-Int is a fixed‑dose oral combination of ibuprofen and paracetamol used to relieve mild to moderate pain, reduce fever, and lessen inflammation associated with conditions such as headaches, musculoskeletal aches, dental procedures, and febrile illnesses.

The product combines two mechanisms: ibuprofen blocks cyclo‑oxygenase enzymes, lowering prostaglandin production to reduce pain, fever, and inflammation; paracetamol acts centrally on a brain‑specific cyclo‑oxygenase variant and serotonergic pathways, providing additional analgesic and antipyretic effects. Together they give additive symptom control.

The appropriate dose is set by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and any relevant medical history. Dosage recommendations are not standardized in this description and should follow the prescriber’s instructions.

Safety data for the combination in pregnancy and lactation are limited. It should only be used if the potential benefit outweighs any risk, and only under medical supervision. Women who are pregnant, planning pregnancy, or breastfeeding should consult their healthcare provider before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Compared with ibuprofen alone, the ibuprofen/paracetamol combination can achieve comparable pain relief and fever reduction at lower individual doses of each component, potentially reducing the risk of gastrointestinal irritation from ibuprofen while adding the central analgesic effect of paracetamol. Clinical choice depends on the patient’s response and safety profile.

Store the product at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep it out of reach of children and do not use after the expiry date indicated on the label.

The medication is taken orally, usually with a full glass of water. It may be taken with or without food, but taking it with food can help minimise stomach discomfort. The exact timing and frequency should follow the prescribing clinician’s directions.

Serious risks include gastrointestinal bleeding (e.g., black stools or vomiting blood), severe skin reactions such as Stevens‑Johnson syndrome, and liver injury manifested by jaundice, dark urine, or elevated liver enzymes. Any of these signs require immediate medical attention.

Individuals with known hypersensitivity to ibuprofen, paracetamol, or any excipients should avoid the product. It is also contraindicated in patients with active peptic ulcer disease, severe liver or kidney impairment, and in children for whom the formulation is not approved. Consultation with a healthcare professional is essential before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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