Product image of Ibuprofen/Paracetamol Alkaloid-Int (Ibuprofen, Paracetamol) supplied by GNH India

Ibuprofen/Paracetamol Alkaloid-Int

Active Ingredient:
Ibuprofen, Paracetamol
Origin:
EU

Ibuprofen/Paracetamol Alkaloid-Int (Ibuprofen, Paracetamol)

Ibuprofen, the active ingredient in Ibuprofen/Paracetamol Alkaloid-Int, is a NSAID and analgesic/antipyretic presented as an oral tablet for oral use. It relieves mild to moderate pain and reduces fever in adults and children when appropriate. The combination of ibuprofen with paracetamol provides complementary mechanisms that can improve symptom control compared with either agent alone.

GNH India supplies Ibuprofen/Paracetamol Alkaloid-Int as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Alkaloid-Int D.O.O.

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Indications & Clinical Uses

Ibuprofen/Paracetamol Alkaloid-Int acts on pain and fever pathways, offering combined analgesic and antipyretic effects.

  • Mild to moderate pain: Provides effective relief when single‑agent therapy is insufficient.
  • Fever: Reduces elevated body temperature in acute febrile states.
  • Headache: Alleviates tension‑type and mild migraine‑related headaches.
  • Musculoskeletal discomfort: Improves comfort in back, joint and muscle aches.
  • Dental pain: Controls pain following dental procedures or infections.

How It Works

  • Ibuprofen inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, decreasing peripheral prostaglandin synthesis and reducing inflammation, pain and fever. Paracetamol acts centrally by inhibiting a variant of COX activity and modulating the endocannabinoid system, producing analgesia and antipyresis without significant peripheral anti‑inflammatory effects. The combined action results in additive pain relief and temperature control.

Side Effects

Side effects may vary in frequency and severity.

Common Side Effects

  • Nausea or upset stomach
  • Heartburn or dyspepsia
  • Dizziness or light‑headedness
  • Mild skin rash
  • Headache
  • Elevated liver enzymes (transient)

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis, angioedema)
  • Gastrointestinal bleeding or ulceration
  • Acute liver injury or failure
  • Renal impairment or failure
  • Blood disorders such as thrombocytopenia

Precautions & Warnings

Use the product with awareness of patient‑specific factors and potential risks.

  • Assess renal function: Avoid in severe renal impairment.
  • Evaluate hepatic status: Use caution in existing liver disease.
  • Avoid in known hypersensitivity to ibuprofen, paracetamol or any excipients.
  • Limit use with other NSAIDs or high‑dose paracetamol to prevent toxicity.
  • Monitor for gastrointestinal symptoms, especially in elderly patients.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Drug interactions can affect safety and efficacy.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.
  • High‑dose paracetamol products: risk of hepatotoxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): enhanced bleeding tendency.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (e.g., ACE inhibitors, diuretics): possible reduction in antihypertensive effect.
  • Lithium: ibuprofen may raise lithium levels.
  • Methotrexate: ibuprofen can increase methotrexate toxicity.
  • Alcohol: combined use may increase liver stress.

Frequently Asked Questions

Ibuprofen/Paracetamol Alkaloid-Int is an over‑the‑counter oral product that combines ibuprofen and paracetamol to provide relief from mild to moderate pain and to lower fever. It is commonly used for headaches, musculoskeletal aches, dental pain and febrile conditions where a single agent may not be sufficient.

Ibuprofen blocks cyclooxygenase enzymes, reducing peripheral prostaglandin production and thereby decreasing inflammation, pain and fever. Paracetamol works mainly in the central nervous system, inhibiting a variant of COX activity and influencing the endocannabinoid system to produce analgesic and antipyretic effects. Together they provide additive symptom control.

The appropriate dose is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition and any concurrent medications. Patients should follow the prescriber’s instructions and the product labeling, and should not exceed the recommended maximum daily amount.

Safety in pregnancy and lactation has not been fully established for this combination. Healthcare providers generally advise caution and may recommend alternative therapies, especially in the first trimester or when breastfeeding. Patients should discuss any concerns with their physician before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

The combination offers complementary mechanisms: ibuprofen provides peripheral anti‑inflammatory action, while paracetamol adds central analgesic and antipyretic effects. This can result in better pain control and fever reduction at lower individual doses, potentially reducing the risk of side effects associated with higher doses of a single agent.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure they are out of reach of children.

The product is taken orally with a glass of water. It may be taken with or without food, although taking it with food can help minimise gastrointestinal discomfort. The exact dosing schedule should follow the prescriber’s guidance.

Serious risks include severe allergic reactions (anaphylaxis), gastrointestinal bleeding or ulceration, acute liver injury, and renal impairment. Patients should seek immediate medical attention if they experience symptoms such as rash, swelling, vomiting blood, dark stools, jaundice or sudden loss of kidney function.

Individuals with known hypersensitivity to ibuprofen, paracetamol, or any excipients should avoid the product. It is also contraindicated in patients with severe liver or kidney disease, active gastrointestinal ulceration, or those taking certain anticoagulants or other NSAIDs without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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