Product image of Ibuprofen/Paracetamol Alkaloid-Int (Ibuprofen, Paracetamol) supplied by GNH India

Ibuprofen/Paracetamol Alkaloid-Int

Active Ingredient:
Ibuprofen, Paracetamol
Origin:
EU

Ibuprofen/Paracetamol Alkaloid-Int (Ibuprofen, Paracetamol)

Ibuprofen/Paracetamol, the active ingredient in Ibuprofen/Paracetamol Alkaloid-Int, is a NSAID and analgesic presented as an oral formulation for oral use. It treats mild to moderate pain and reduces fever in adults and children.

GNH India supplies Ibuprofen/Paracetamol Alkaloid-Int as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Alkaloid-Int D.O.O.

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Indications & Clinical Uses

Ibuprofen/Paracetamol combines an NSAID and an analgesic to address pain and fever.

  • Mild to moderate pain: provides analgesic relief for conditions such as dental pain, menstrual cramps, and minor injuries.
  • Fever: helps lower elevated body temperature associated with infections or inflammatory states.
  • Headache: reduces intensity of tension‑type and mild migraine headaches.
  • Musculoskeletal pain: eases discomfort from strains, sprains, and low‑back pain.

How It Works

  • Ibuprofen blocks cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing peripheral prostaglandin synthesis and thereby producing anti‑inflammatory, analgesic and antipyretic effects. Paracetamol acts centrally to inhibit COX activity and modulates the endocannabinoid system, contributing to analgesia and fever reduction without significant peripheral anti‑inflammatory activity.

Side Effects

Common Side Effects

  • Nausea: mild stomach upset that may occur after dosing.
  • Dyspepsia: discomfort or burning sensation in the upper abdomen.
  • Dizziness: transient light‑headedness, especially with rapid standing.
  • Rash: mild skin irritation or itching.

Serious or Rare Side Effects

  • Gastrointestinal bleeding: black stools or vomiting of blood.
  • Severe liver injury: jaundice, dark urine, or elevated liver enzymes.
  • Acute kidney injury: reduced urine output or swelling of the limbs.

Precautions & Warnings

Before using Ibuprofen/Paracetamol, consider the following precautions.

  • Assess renal function: avoid in patients with severe renal impairment.
  • Monitor hepatic function: use cautiously in liver disease.
  • Check for hypersensitivity: discontinue if allergic reaction occurs.
  • Use lowest effective dose: limit duration to reduce gastrointestinal and renal risks.
  • Pregnancy and breastfeeding: consult a healthcare professional before use.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Ibuprofen/Paracetamol may interact with other medicines; review the following groups.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.
  • High‑dose paracetamol products: risk of hepatotoxicity.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (e.g., ACE inhibitors, ARBs): possible reduction in blood pressure control.
  • Diuretics: may impair renal function when combined.
  • Methotrexate: potential for increased toxicity due to reduced clearance.

Frequently Asked Questions

Ibuprofen/Paracetamol Alkaloid-Int is an over‑the‑counter oral product that combines an NSAID and an analgesic. It is indicated for the relief of mild to moderate pain such as dental, musculoskeletal, and headache pain, as well as for reducing fever associated with common infections.

Ibuprofen inhibits cyclooxygenase‑1 and‑2 enzymes, lowering peripheral prostaglandin production and providing anti‑inflammatory, analgesic, and antipyretic effects. Paracetamol acts mainly in the central nervous system to inhibit COX activity and modulate the endocannabinoid system, adding further pain relief and fever reduction without strong peripheral anti‑inflammatory action.

The appropriate dose and dosing interval are determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and other medications. Patients should follow the prescriber’s instructions and the product label guidance.

Safety in pregnancy and lactation has not been fully established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the use of Ibuprofen/Paracetamol with their healthcare provider to weigh potential benefits against possible risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

The combination provides additive analgesic and antipyretic effects because ibuprofen and paracetamol act via different mechanisms. This can result in better pain control and fever reduction at lower individual doses compared with ibuprofen alone, potentially reducing the risk of dose‑related side effects.

Ibuprofen/Paracetamol Alkaloid-Int should be stored at ambient temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

The product is taken orally with a glass of water. It can be taken with or without food, but taking it with food may reduce the likelihood of gastrointestinal discomfort. Swallow tablets whole; do not crush or chew unless instructed otherwise.

Serious risks include gastrointestinal bleeding, severe liver injury, and acute kidney impairment. Patients should seek immediate medical attention if they notice black stools, yellowing of the skin or eyes, reduced urine output, or unexplained swelling.

Individuals with known hypersensitivity to ibuprofen, other NSAIDs, or paracetamol should avoid this product. It is also contraindicated in patients with severe renal or hepatic impairment, active peptic ulcer disease, and those taking anticoagulants without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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