Ibuprofen/Paracetamol Hexal (Ibuprofen, Paracetamol)

Ibuprofen/Paracetamol Hexal works on inflammatory and pain pathways to reduce discomfort and lower temperature.

• Headache: provides rapid relief of tension‑type or mild migraine pain.
• Fever: lowers elevated body temperature associated with viral or bacterial infections.
• Musculoskeletal pain: eases aches from strains, sprains, osteoarthritis or back pain.
• Dental pain: reduces pain after dental procedures or toothache.
• Post‑operative pain: helps control mild to moderate pain after minor surgery.

• Ibuprofen inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing prostaglandin synthesis and thereby reducing inflammation, pain and fever. Paracetamol acts centrally, likely inhibiting a variant of COX in the brain and modulating serotonergic pathways, which contributes to analgesia and antipyresis. The combination provides complementary peripheral and central mechanisms for symptom control.

Common Side Effects

• Gastrointestinal discomfort: mild stomach pain, dyspepsia or heartburn.
• Nausea or vomiting: occasional upset stomach after ingestion.
• Dizziness or light‑headedness: transient sensation of imbalance.
• Skin rash: mild erythema or itching at the site of contact.

Serious or Rare Side Effects

• Hepatic injury: signs of liver dysfunction such as jaundice.
• Severe allergic reaction: swelling of face, lips, or throat, difficulty breathing.
• Gastrointestinal bleeding or ulceration: black stools or vomiting blood.
• Renal impairment: reduced urine output or swelling of limbs.
• Stevens‑Johnson syndrome or toxic epidermal necrolysis: widespread skin blistering.

Before using Ibuprofen/Paracetamol Hexal, consider the following precautions.

• Liver function assessment: evaluate hepatic health, especially with chronic use.
• Renal function assessment: monitor kidney status in patients with existing impairment.
• Hypersensitivity: avoid if known allergy to ibuprofen, paracetamol, or other NSAIDs.
• Alcohol consumption: limit intake as combined use may increase liver risk.
• Elderly patients: use lower doses and monitor for adverse effects.
• Pregnancy (third trimester): avoid due to potential fetal risks.
• Store at ambient temperature: keep in the original pack, protect from moisture.

Ibuprofen/Paracetamol Hexal may interact with other medicines.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.
• High‑dose paracetamol products: risk of hepatic overload.
• Lithium: ibuprofen may raise lithium serum levels.
• Methotrexate: ibuprofen can reduce clearance, raising toxicity.

Moderate Interactions (Monitor Closely):\n- Antihypertensives (e.g., ACE inhibitors, ARBs): possible reduction in blood pressure control.

• Diuretics: may worsen renal function when combined.
• Selective serotonin reuptake inhibitors (SSRIs): modest increase in bleeding tendency.
• Alcohol: additive liver stress.
• CYP2C9 substrates (e.g., phenytoin): ibuprofen may alter metabolism.