Product image of Ibuprofen Pfleger (Ibuprofen D,l-Lysinate) supplied by GNH India

Ibuprofen Pfleger

Active Ingredient:
Ibuprofen D,l-Lysinate
Origin:
EU

Ibuprofen Pfleger (Ibuprofen D,l-Lysinate)

Ibuprofen D,l-Lysinate, the active ingredient in Ibuprofen Pfleger, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It reduces pain, fever, and inflammation by inhibiting cyclooxygenase enzymes, and is indicated for mild to moderate pain, fever, and inflammatory disorders such as arthritis in adult patients.

GNH India supplies Ibuprofen Pfleger as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality manufacturing standards and reliable global distribution.

Manufacturer / TM Owner

Dr. Pfleger Arzneimittel Gmbh

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Indications & Clinical Uses

Ibuprofen Pfleger, an NSAID that reduces prostaglandin synthesis, is used for the following clinical indications:

  • Mild to moderate pain: provides analgesic relief for headaches, dental pain, and musculoskeletal discomfort.
  • Fever: lowers elevated body temperature associated with infections or inflammatory states.
  • Arthritis: alleviates joint pain and swelling in osteoarthritis and rheumatoid arthritis.

How It Works

  • Ibuprofen D,l-Lysinate exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which decreases the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin levels diminish peripheral sensitization of nociceptors, lower the hypothalamic set‑point for temperature, and limit inflammatory exudate formation, thereby providing analgesic, antipyretic, and anti‑inflammatory actions.

Side Effects

Ibuprofen may cause a range of adverse reactions, varying from common to serious.

Common Side Effects

  • Nausea: mild stomach upset or queasiness.
  • Headache: transient head pain.
  • Dyspepsia: indigestion or heartburn.

Serious or Rare Side Effects

  • Gastrointestinal bleeding: potentially life‑threatening bleeding in the stomach or intestines.
  • Renal impairment: reduced kidney function, especially with prolonged use.
  • Severe allergic reaction: skin rash, swelling, or anaphylaxis.

Precautions & Warnings

Before using Ibuprofen Pfleger, consider the following precautions:

  • Assess renal function: avoid use in patients with severe kidney disease.
  • Monitor gastrointestinal risk: use with food or protective agents in those with ulcer history.
  • Avoid in known hypersensitivity: discontinue if allergic reactions occur.
  • Limit duration: use the lowest effective dose for the shortest time needed.
  • Pregnancy and lactation: consult a healthcare provider before use.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.

Avoid Interactions

Ibuprofen Pfleger can interact with other medicines. Review the following categories:

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal function.
  • Diuretics: risk of reduced kidney perfusion.
  • Lithium: may increase lithium serum levels.

Frequently Asked Questions

Ibuprofen Pfleger is an oral NSAID indicated for the relief of mild to moderate pain, reduction of fever, and management of inflammatory conditions such as osteoarthritis and rheumatoid arthritis. It works by decreasing prostaglandin production, which helps control pain and swelling.

Ibuprofen D,l-Lysinate inhibits both COX‑1 and COX‑2 enzymes, blocking the synthesis of prostaglandins that mediate pain, fever, and inflammation. By lowering prostaglandin levels, the drug reduces peripheral sensitization of nerves, lowers the hypothalamic temperature set‑point, and diminishes inflammatory exudate.

The appropriate dose of Ibuprofen Pfleger is determined by a qualified prescriber based on the individual’s condition, age, weight, and response to therapy. Patients should follow the prescribing information and never exceed the recommended amount without medical advice.

Safety of ibuprofen during pregnancy and lactation depends on the trimester and clinical circumstances. It is generally avoided in the third trimester and should only be used in pregnancy or while breastfeeding when clearly needed and after consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ibuprofen Pfleger offers a similar efficacy profile to other non‑selective NSAIDs such as naproxen or diclofenac, but its D,l‑lysinate salt may provide improved gastrointestinal tolerance in some patients. Choice of NSAID often depends on individual risk factors, dosing frequency, and physician preference.

Store Ibuprofen Pfleger at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Ibuprofen Pfleger is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food may reduce the likelihood of stomach upset. Follow the prescriber’s instructions regarding timing and frequency.

The most serious risks include gastrointestinal bleeding or ulcer perforation, severe renal impairment, and hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience signs of serious bleeding, sudden kidney problems, or severe allergic symptoms.

Individuals with a known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal ulcers, severe heart failure, or advanced renal disease should avoid Ibuprofen Pfleger. It is also contraindicated in the third trimester of pregnancy and in patients taking certain anticoagulants without close monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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